Department of Urology, Isala Clinics, Zwolle, The Netherlands.
Department of General Practice, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
J Urol. 2014 Apr;191(4):1028-33. doi: 10.1016/j.juro.2013.10.100. Epub 2013 Oct 29.
We determined the relationship between nocturia and nocturnal polyuria.
The PubMed® and Embase® databases were searched for studies written in English, German, French or Dutch with original data on adult participants in an investigation of the relationship between nocturia and nocturnal polyuria. A meta-analysis of the difference in mean nocturnal voiding frequencies between patients with and without nocturnal polyuria was conducted. Nocturnal polyuria risk was compared between participants with and without nocturia, and the resulting odds ratio was subsequently converted to relative risk with 95% CIs.
From 511 references identified we selected 78 publications of 66 studies, 15 of which met the inclusion criteria for this study. Quality scores of studies were generally high for internal validity but low for external validity. In 7 studies (1,416 participants) we estimated a standardized mean difference of 0.59 (95% CI 0.29-0.89) for nocturnal voids between nocturnal polyuria and nonnocturnal polyuria cases. In 8 other studies (with 2,320 participants) we calculated a pooled OR of 4.99 (3.92-6.37) for nocturnal polyuria in individuals with nocturia. The corresponding RR, based on a nocturnal polyuria risk in the pooled population of 63.8%, was 1.41 (1.37-1.44).
The association between nocturia and nocturnal polyuria is apparent and robust. However, the clinical importance of the association appears to be less obvious than previously suggested based on single studies. The observed high prevalence of nocturnal polyuria, as a result of the applied International Continence Society definition, may be responsible for this discrepancy.
我们确定了夜尿症与夜间多尿之间的关系。
检索了 PubMed® 和 Embase® 数据库中以英文、德文、法文或荷兰文撰写的研究报告，这些研究报告均包含关于成人夜尿症与夜间多尿关系的原始数据。对患有夜间多尿症与不患有夜间多尿症的患者之间夜间平均排尿次数的差异进行了荟萃分析。比较了有夜尿症与无夜尿症的参与者之间夜间多尿症的风险，随后将得出的比值比转换为具有 95%CI 的相对风险。
从 511 篇参考文献中，我们选择了 78 篇出版物的 66 项研究，其中 15 项符合本研究的纳入标准。研究的内部有效性的质量评分通常较高，但外部有效性的质量评分较低。在 7 项研究（1416 名参与者）中，我们估计夜间多尿症和非夜间多尿症病例之间夜间排尿次数的标准化均数差值为 0.59（95%CI 0.29-0.89）。在另外 8 项研究（共 2320 名参与者）中，我们计算出夜尿症患者发生夜间多尿症的合并比值比为 4.99（3.92-6.37）。基于合并人群中夜间多尿症风险为 63.8%，得出的合并相对危险度为 1.41（1.37-1.44）。
夜尿症与夜间多尿之间的关联是明显且可靠的。然而，与之前基于单项研究提出的建议相比，这种关联的临床重要性似乎不那么明显。观察到的高夜间多尿症患病率（由于采用了国际尿控协会的定义）可能是造成这种差异的原因。
