病理性视网膜病中的生物活性脂质。

Bioactive lipids in pathological retinopathy.

机构信息

a Department of Food Science and Nutrition , Zhejiang University , Hangzhou , 310029 , China.

出版信息

Crit Rev Food Sci Nutr. 2014;54(1):1-16. doi: 10.1080/10408398.2011.565523.

DOI:10.1080/10408398.2011.565523

Abstract

Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions.

摘要

糖尿病性视网膜病变是一种常见的疾病，发生于长期高血糖的糖尿病患者，其特征为异常血管生成。这种病理性血管生成可能是内皮损伤的一种生理性增殖反应。最近的研究表明，活性氧（ROS）在这种血管生成中起重要作用。血管内皮生长因子（VEGF）是一种有效的血管生成生长因子，在糖尿病性视网膜病变中起重要作用。VEGF 与 ROS 之间的相互作用，以及它们与促炎和抗炎细胞因子以及抗炎生物活性脂质分子（如脂氧素、解析素、保护素和maresin）之间的相互作用，对于理解糖尿病性视网膜病变的病理生理学和开发未来的治疗干预措施特别相关。