Iwamoto E T
Alcohol Drug Res. 1985;6(4):265-76.
The pharmacologic properties of phencyclidine were assessed in adult, male rats using a three-chambered, place-conditioning apparatus. Phencyclidine hydrochloride (PCP), at doses of 0.5 to 4 mg/kg, produced a dose-related place-aversion after three drug/environment pairings. During the place-conditioning procedure, 4 mg/kg of PCP significantly increased spontaneous locomotor activity compared to saline-control. Tolerance to PCP-induced place-aversion developed after four daily administrations of 4 mg/kg of PCP. d-Butaclamol, 0.4 mg/kg, given 1 min before each of the three conditioning-doses of PCP decreased the development of the place-aversion induced by PCP. 1-Butaclamol was without significant effect. Spiroperidol, 0.06 mg/kg, completely blocked the development of PCP place-aversion. Spiroperidol and the stereoisomers of butaclamol did not have significant place-conditioning activity when administered alone in the place-conditioning paradigm. The data suggest that PCP induces place-aversion in rats in the place-conditioning model, and that tolerance to this effect develops within 4 days. Furthermore, since d-butaclamol or spiroperidol, but not 1-butaclamol, antagonized this effect of PCP, PCP-induced place-aversion may be mediated in part by a dopaminergic mechanism.
使用三室位置条件化装置，对成年雄性大鼠的苯环利定药理特性进行了评估。盐酸苯环利定（PCP）剂量为0.5至4mg/kg，在三次药物/环境配对后产生剂量相关的位置厌恶。在位置条件化过程中，与生理盐水对照相比，4mg/kg的PCP显著增加了自发运动活性。在每日给予4mg/kg的PCP四次后，对PCP诱导的位置厌恶产生了耐受性。在每次给予PCP的三个条件剂量前1分钟给予0.4mg/kg的d-布他拉莫，可减少PCP诱导的位置厌恶的形成。l-布他拉莫无显著作用。0.06mg/kg的螺哌啶完全阻断了PCP位置厌恶的形成。在位置条件化范式中单独给药时，螺哌啶和布他拉莫的立体异构体没有显著的位置条件化活性。数据表明，在位置条件化模型中，PCP在大鼠中诱导位置厌恶，并且对这种效应的耐受性在4天内形成。此外，由于d-布他拉莫或螺哌啶（而非l-布他拉莫）拮抗了PCP的这种效应，PCP诱导的位置厌恶可能部分由多巴胺能机制介导。
