Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China.
Mol Biol Rep. 2013 Dec;40(12):7077-82. doi: 10.1007/s11033-013-2830-x. Epub 2013 Nov 5.
Genetic factors play an important role in the Alzheimer's disease (AD) development and memory impairment is a cardinal clinical feature of AD. Kidney and brain expressed protein (KIBRA), owing to its connection with human episodic memory, became an interesting candidate gene for AD. Recently, KIBRA (rs17070145) was reported to be associated with AD in the genetic and functional levels in Caucasian and African-American, and the association might be different across age groups. To investigate the possibility of age-dependent association of KIBRA with AD in Asian, we conducted an independent replication study in a cohort of 1,586 subjects from Han Chinese (including 790 LOAD patients and 796 healthy controls). The results revealed no significant differences in the distributions of genotype or allele between LOAD and control groups in the total sample. However, when these data were stratified by their age, we observed a significant difference in the genotypes and alleles frequencies (genotype: p = 0.004, allele: p = 0.035) in the young subgroup. Moreover, the association was further demonstrated in logistic regression analysis (rs17070145: p = 0.045, OR = 0.428). Our data suggested that KIBRA might associate with younger AD patients (≤74 years) in a Northern Han Chinese population.
遗传因素在阿尔茨海默病（AD）的发展中起着重要作用，而记忆障碍是 AD 的主要临床特征。肾脏和脑表达蛋白（KIBRA）由于与人类情景记忆有关，成为 AD 的一个有趣的候选基因。最近，KIBRA（rs17070145）在白人和非裔美国人的遗传和功能水平上被报道与 AD 有关，这种关联可能在不同年龄组之间存在差异。为了研究 KIBRA 在亚洲人群中与 AD 相关的年龄依赖性，我们在来自汉族的 1586 名受试者队列中进行了一项独立的复制研究（包括 790 名 LOAD 患者和 796 名健康对照者）。结果显示，在总样本中，LOAD 组和对照组在基因型或等位基因的分布上没有显著差异。然而，当按年龄对这些数据进行分层时，我们观察到年轻亚组中基因型和等位基因频率存在显著差异（基因型：p=0.004，等位基因：p=0.035）。此外，逻辑回归分析进一步证明了这种关联（rs17070145：p=0.045，OR=0.428）。我们的数据表明，在北方汉族人群中，KIBRA 可能与较年轻的 AD 患者（≤74 岁）相关。
