Chen Doris, Yu Wanjia, Aitken Laura, Gunn-Moore Frank
School of Biology, University of St. Andrews, St. Andrews KY16 9TF, UK.
Cells. 2021 Nov 4;10(11):3024. doi: 10.3390/cells10113024.
The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer's disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.
含FERM结构域蛋白6（FRMD6），也称为Willin，是Hippo信号通路的上游调节因子，最近研究表明它可通过ERK信号通路调节神经元细胞的肌动蛋白细胞骨架动力学和机械表型。Willin/FRMD6在神经系统中的生理功能包括神经元分化、髓鞘形成、神经损伤修复和囊泡胞吐作用。鉴于越来越多的证据表明Willin/FRMD6在阿尔茨海默病（AD）中发挥作用，包括一系列全基因组关联研究将Willin/FRMD6定位为一种新的AD风险基因，Willin/FRMD6新确立的神经元作用尤其令人关注。在此，我们描述了关于Willin/FRMD6在神经系统中的作用及其在与AD发病机制相关的细胞扰动中的作用的最新研究结果。
