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全血浆同型半胱氨酸:一些常见生理变量的影响。

Total plasma homocysteine: influence of some common physiological variables.

机构信息

Istituto Scientifico, Hosp. San Raffaele, Milan, Italy.

出版信息

Amino Acids. 1993 Feb;5(1):17-21. doi: 10.1007/BF00806188.

DOI:10.1007/BF00806188
PMID:24190640
Abstract

The purpose of this study was to investigate H(e) concentration in plasma from 80 healthy donors in relation to age (6 newborns are also included), sex, daily variation (9, 11 a.m.; 2, 6, 12 p.m.) and a period of 5 subsequent months. A significant correlation (r = 0.63, p < 0.001) was observed between plasma H(e) and age and a statistical difference (p < 0.05) was found between female and male. No circadian rhythm or significant variations over 5 months were found.

摘要

本研究旨在探讨 80 名健康供体的血浆中 H(e)浓度与年龄(包括 6 名新生儿)、性别、日变化(上午 9 点和 11 点;下午 2 点、6 点和 12 点)以及随后 5 个月的关系。观察到血浆 H(e)与年龄之间存在显著相关性(r = 0.63,p < 0.001),并且在女性和男性之间发现了统计学差异(p < 0.05)。未发现昼夜节律或 5 个月内的显著变化。

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本文引用的文献

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Unbound amino acid concentrations in plasma and erythrocytes of normal children and of cord blood.正常儿童及脐血血浆和红细胞中游离氨基酸浓度
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The effect of D-penicillamine on protein-bound homocyst(e)ine in homocystinurics.青霉胺对同型胱氨酸尿症患者中蛋白结合型同型半胱氨酸(或同型胱氨酸)的影响
Pediatr Res. 1982 May;16(5):370-2. doi: 10.1203/00006450-198205000-00010.
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Unique efficiency of methionine metabolism in premenopausal women may protect against vascular disease in the reproductive years.绝经前女性甲硫氨酸代谢的独特效率可能在生育期预防血管疾病。
J Clin Invest. 1983 Dec;72(6):1971-6. doi: 10.1172/JCI111161.
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Emergency care for acute poisoning with phosphororganic compounds.
Metabolism. 1973 Apr;22(4):571-8. doi: 10.1016/0026-0495(73)90070-x.
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Plasma free amino acid values in normal children and adolescents.
Metabolism. 1986 Oct;35(10):967-9. doi: 10.1016/0026-0495(86)90063-6.
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Differences between premenopausal women and young men in the transamination pathway of methionine catabolism, and the protection against vascular disease.绝经前女性与年轻男性在蛋氨酸分解代谢转氨途径上的差异以及对血管疾病的保护作用。
Eur J Clin Invest. 1988 Dec;18(6):633-8. doi: 10.1111/j.1365-2362.1988.tb01279.x.
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Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease.外周动脉闭塞性疾病患者高同型半胱氨酸血症的患病率。
Circulation. 1989 Jun;79(6):1180-8. doi: 10.1161/01.cir.79.6.1180.
10
Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.血浆同型半胱氨酸,一种血管疾病的危险因素:健康、疾病及药物治疗状态下的血浆水平
J Lab Clin Med. 1989 Nov;114(5):473-501.