Tavares Bárbara, Santos Lopes Susana
Centro de Estudos de Doenças Crónicas. Faculdade de Ciências Médicas de Lisboa. Lisboa. Portugal.
Acta Med Port. 2013 Sep-Oct;26(5):583-92. Epub 2013 Oct 31.
Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are small, transparent and undergo rapid external development.
Using scientific literature research tools available online and the keywords Zebrafish, biomedical research, human disease, and drug screening, we reviewed original studies and reviews indexed in PubMed.
In this review we summarized work conducted with this model for the advancement of our knowledge related to several human diseases. We also focused on the biomedical research being performed in Portugal with the zebrafish model.
Powerful live imaging and genetic tools are currently available for zebrafish making it a valuable model in biomedical research. The combination of these properties with the optimization of automated systems for drug screening has transformed the zebrafish into "a top model" in biomedical research, drug discovery and toxicity testing. Furthermore, with the optimization of xenografts technology it will be possible to use zebrafish to aide in the choice of the best therapy for each patient.
Zebrafish is an excellent model organism in biomedical research, drug development and in clinical therapy.
斑马鱼（Danio rerio）是研究脊椎动物发育的理想模式生物。这是因为每对斑马鱼能产出大量鱼卵，每7天可达200个胚胎，而且胚胎和幼体体积小、透明，且在体外快速发育。
我们使用在线科学文献研究工具，以斑马鱼、生物医学研究、人类疾病和药物筛选为关键词，对PubMed中索引的原始研究和综述进行了回顾。
在本综述中，我们总结了利用该模式开展的工作，以增进我们对几种人类疾病的了解。我们还重点介绍了葡萄牙利用斑马鱼模型开展的生物医学研究。
目前有强大的活体成像和基因工具可用于斑马鱼研究，使其成为生物医学研究中有价值的模型。这些特性与药物筛选自动化系统的优化相结合，已将斑马鱼转变为生物医学研究、药物发现和毒性测试中的“顶级模型”。此外，随着异种移植技术的优化，将有可能利用斑马鱼协助为每位患者选择最佳治疗方案。
斑马鱼是生物医学研究、药物开发和临床治疗中的优秀模式生物。
