Gelles Katharina, Butylina Maria, Pietschmann Peter
Gerontology. 2025 May 20:1-29. doi: 10.1159/000546107.
Osteoporosis is a frequent age-related skeletal disorder, wielding an enormous influence on the quality of life of many women, but also men. Osteoporosis results from a shifted ratio between the activity of osteoblasts and osteoclasts resulting in an increased degradation of bone. This leads to a systemic impairment of bone mass and microarchitecture. Currently only a small number of patients with osteoporosis is treated adequately, making the disease an enormous economic burden. This implies the urgent need of developing new treatment strategies and application mechanisms. Therefore, animal models are of great importance for the investigation and treatment of bone diseases.
In this narrative review we focus on animal models specially used for age-related osteoporosis including mice, fish and large animal models.
With this manuscript we want to contribute to the identification of novel treatment strategies for the treatment of age-related osteoporosis.
骨质疏松症是一种常见的与年龄相关的骨骼疾病，对许多女性乃至男性的生活质量都有巨大影响。骨质疏松症是由成骨细胞和破骨细胞活性比例失衡导致骨降解增加引起的。这会导致骨量和微结构的系统性损害。目前只有少数骨质疏松症患者得到了充分治疗，这使得该疾病成为巨大的经济负担。这意味着迫切需要开发新的治疗策略和应用机制。因此，动物模型对于骨疾病的研究和治疗至关重要。
在这篇叙述性综述中，我们重点关注专门用于与年龄相关骨质疏松症的动物模型，包括小鼠、鱼类和大型动物模型。
通过本手稿，我们希望为确定治疗与年龄相关骨质疏松症的新治疗策略做出贡献。
