Mallick Saumyaranjan, Ghosh Ranajoy, Iyer Venkateswaran K, Jain Deepali, Mathur Sandeep R
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Acta Cytol. 2013;57(6):625-32. doi: 10.1159/000354947. Epub 2013 Oct 26.
Rosai-Dorfman disease (RDD) is a rare benign idiopathic histiocytic proliferation. Most commonly reported cases are lymph nodal. Only 30-40% of cases occur in extranodal sites. Although the morphological features of RDD are well documented, there is limited information about the morphometric variations in the histiocytes of this entity.
Twenty-two cases of RDD diagnosed on fine-needle aspiration cytology (FNAC) were retrieved from the archives. Both Papanicolaou- and May-Grünwald-Giemsa-stained slides were available for evaluation in all cases. Nuclear area, diameter and histiocyte size were measured taking reactive histiocytes as controls.
Among the 22 patients (male/female ratio 3:2; age range 5-55 years, mean 26 years), 3 cases were extranodal and 19 cases were nodal. The nodal sites included cervical, axillary, inguinal and submandibular lymph nodes. The extranodal sites were the retroperitoneum, mediastinum and skin. The most common clinical presentation was enlarged lymph nodes. Cytological features included numerous large benign histiocytes with emperipolesis. All the morphometric parameters were significantly (p < 0.01) higher in RDD histiocytes than in histiocytes in the reactive lymph node.
In view of the rarity of the disease and the variable clinical presentation in RDD, accurate diagnosis is necessary. This is the first study to document the morphometric parameters of RDD histiocytes and their comparison with histiocytes in the reactive lymph node.
罗萨伊-多夫曼病（RDD）是一种罕见的良性特发性组织细胞增生症。最常报道的病例发生在淋巴结。仅30%-40%的病例发生在结外部位。尽管RDD的形态学特征已有充分记录，但关于该实体组织细胞形态计量学变化的信息有限。
从档案中检索出22例经细针穿刺细胞学检查（FNAC）诊断为RDD的病例。所有病例均有巴氏染色和迈-格-姬染色玻片可供评估。以反应性组织细胞作为对照，测量核面积、直径和组织细胞大小。
22例患者中（男/女比例为3:2；年龄范围5-55岁，平均26岁），3例为结外病变，19例为淋巴结病变。淋巴结部位包括颈部、腋窝、腹股沟和下颌下淋巴结。结外部位为腹膜后、纵隔和皮肤。最常见的临床表现为淋巴结肿大。细胞学特征包括大量具有吞噬现象的大的良性组织细胞。RDD组织细胞的所有形态计量学参数均显著高于反应性淋巴结中的组织细胞（p<0.01）。
鉴于该疾病的罕见性以及RDD临床表现的多样性，准确诊断很有必要。这是第一项记录RDD组织细胞形态计量学参数及其与反应性淋巴结中组织细胞比较的研究。
