Chhabra Sonia, Agarwal Ruchi, Garg Shilpa, Singh Harpreet, Singh Sunita
Department of Pathology, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana.
Diagn Cytopathol. 2012 May;40(5):447-9. doi: 10.1002/dc.21737. Epub 2011 May 31.
Rosai-Dorfman Disease (RDD) or Sinus Histiocytosis with Massive Lymphadenopathy (SHML) is a rare disorder typically manifesting as enlarged lymph nodes with or without systemic involvement. These cases are often clinically misdiagnosed as lymphoma. Recognising this entity to distinguish it from lymphoma and other causes of histiocytosis is important because of different treatment modalities for these disorders. Extranodal involvement is also common, often with a particular predilection for the head and neck region. We report a rare case of Rosai-Dorfman Disease with both nodal and extranodal involvement in a 33-year-old woman. The patient had bilateral cervical lymphadenopathy and diffuse thyroid enlargement. Thyroid gland involvement in RDD diagnosed on fine needle aspiration cytology (FNAC) has rarely been reported in literature. FNAC is a useful and reliable tool for the diagnosis of RDD and the biopsy can be avoided in these patients, thus reducing inconvenience to patients.
罗萨伊-多夫曼病（RDD）或伴有巨大淋巴结病的窦性组织细胞增生症（SHML）是一种罕见疾病，通常表现为淋巴结肿大，可伴有或不伴有全身受累。这些病例临床上常被误诊为淋巴瘤。认识到这一实体并将其与淋巴瘤及其他组织细胞增多症病因相区分很重要，因为这些疾病的治疗方式不同。结外受累也很常见，通常特别好发于头颈部区域。我们报告一例33岁女性罕见的罗萨伊-多夫曼病病例，同时有淋巴结和结外受累。该患者有双侧颈部淋巴结肿大和弥漫性甲状腺肿大。甲状腺细针穿刺细胞学检查（FNAC）诊断为罗萨伊-多夫曼病累及甲状腺，这在文献中鲜有报道。FNAC是诊断罗萨伊-多夫曼病的一种有用且可靠的工具，这些患者可避免活检，从而减少患者的不便。
