Medical Oncology 1, Veneto Institute of Oncology - IRCCS, Padua, Italy.
Chemotherapy. 2013;59(3):176-80. doi: 10.1159/000355662. Epub 2013 Oct 31.
Anaplastic ependymomas are rare tumors in adult patients. Maximal safe resection and use of radiation therapy are standard treatment approaches in patients with anaplastic ependymoma. Recurrent anaplastic ependymomas are treated by reoperation when the tumors are surgically accessible, by radiotherapy if not previously administered and by salvage chemotherapy. However, the role of chemotherapy is still unclear. A few retrospective studies showed interesting results with platinum-based regimens, while the administration of temozolomide alone demonstrated conflicting results. We present, for the first time, the case of a patient with anaplastic ependymoma refractory to platinum-based chemotherapy and temozolomide only, but showing a prolonged reduction of the lesion after receiving combination chemotherapy with cisplatin and temozolomide. A brief review of the literature on the treatment of anaplastic ependymoma follows.
间变室管膜瘤在成年患者中较为罕见。最大安全切除和放疗是间变室管膜瘤患者的标准治疗方法。对于复发性间变室管膜瘤，如果肿瘤可手术切除，则再次手术切除，如果之前未行放疗，则行放疗，如果无法手术切除且无放疗禁忌证，则行挽救性化疗。然而，化疗的作用仍不清楚。少数回顾性研究显示含铂方案具有令人感兴趣的结果，而单独使用替莫唑胺的结果则相互矛盾。我们首次报道了一例对铂类化疗和替莫唑胺均耐药的间变室管膜瘤患者，但在接受顺铂和替莫唑胺联合化疗后，病变得到了长时间的缩小。本文简要回顾了间变室管膜瘤的治疗文献。
