Clinic of Nephrology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany.
Amino Acids. 1992 Jun;3(2):173-82. doi: 10.1007/BF00806782.
Acidosis is a common finding in uremia. We analysed the effect of changes in acid-base balance in 42 Sprague-Dawley rats having longstanding uremia (> 3 mon). The rats were treated with CaCO3 or CaCl2 in a random cross-over trial after being divided into two dietary groups (8% or 18% protein). At the end of each observation period parameters were assessed. The main finding was that plasma amino and keto acid concentrations varied significantly with the acid-base balance and the protein intake. Furthermore a considerable degree of catabolism and anorexia was observed. In addition other confounding variables were observed, e.g. increased corticosterone excretion, electrolyte losses, and proteinuria. Our data underline that plasma amino acid concentrations in uremic rats are highly dependent on acid-base balance and overall protein intake.
酸中毒是尿毒症的常见表现。我们分析了酸碱平衡变化对 42 只 Sprague-Dawley 大鼠（慢性肾衰竭>3 个月）的影响。将大鼠分为两组（8%或 18%蛋白质），进行碳酸钙或氯化钙的随机交叉试验治疗。在每个观察期结束时评估参数。主要发现是，血浆氨基酸和酮酸浓度随酸碱平衡和蛋白质摄入而显著变化。此外，还观察到一定程度的分解代谢和厌食。此外，还观察到其他混杂变量，如皮质酮排泄增加、电解质丢失和蛋白尿。我们的数据表明，尿毒症大鼠的血浆氨基酸浓度高度依赖于酸碱平衡和总蛋白质摄入。
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