Kaye M
J Clin Invest. 1974 Jan;53(1):256-69. doi: 10.1172/JCI107546.
Renal failure of 4 wk duration in rats led to parathyroid enlargement, increased bone resorption, and decreased tubular reabsorption of phosphate by the remnant kidney. The degree of hyperparathyroidism was influenced by each of the three dietary factors investigated. In the first study increasing calcium intake reduced the size of the parathyroids by increasing calcium and reducing phosphate absorption. In the second study phosphate intake was linearly related to parathyroid gland size in the uremic animals and associated with rising plasma phosphate levels. In the last study acidosis led directly to increased bone resorption but small parathyroid glands associated with elevated ionized calcium levels. Alkalosis lowered the serum ionized calcium and led to parathyroid enlargement and the expected associated findings. It was shown that parathyroid weight reflected both metabolic activity as judged by amino acid uptake, and the content of immunoassayable parathyroid hormone. In all studies gland weight was inversely related to serum ionized calcium.
大鼠持续4周的肾衰竭导致甲状旁腺肿大、骨吸收增加以及残余肾脏对磷酸盐的肾小管重吸收减少。甲状旁腺功能亢进的程度受所研究的三种饮食因素中每一种的影响。在第一项研究中，增加钙摄入量通过增加钙吸收和减少磷酸盐吸收来减小甲状旁腺的大小。在第二项研究中，磷酸盐摄入量与尿毒症动物的甲状旁腺大小呈线性相关，并与血浆磷酸盐水平升高有关。在最后一项研究中，酸中毒直接导致骨吸收增加，但甲状旁腺较小，与离子钙水平升高有关。碱中毒降低了血清离子钙水平，导致甲状旁腺肿大以及预期的相关表现。结果表明，甲状旁腺重量既反映了通过氨基酸摄取判断的代谢活性，也反映了可免疫测定的甲状旁腺激素的含量。在所有研究中，腺体重量与血清离子钙呈负相关。
