Zhu Minwei, Wang Xudong, Gao Wenpeng, Shi Chen, Ge Haitao, Shen Hong, Lin Zhiguo
Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, PR China.
Dement Geriatr Cogn Disord. 2014;37(3-4):214-22. doi: 10.1159/000350410. Epub 2013 Oct 26.
We investigated the rate of corpus callosum (CC) atrophy and its association with cognitive decline in early Alzheimer's disease (AD).
We used publicly available longitudinal MRI data corresponding to 2 or more visits from 137 subjects characterized using the Clinical Dementia Rating (CDR) score. We classified these subjects into 3 groups according to the progression of their cognitive status: a healthy control group (CDR 0→0, n = 72), a decliner group (CDR 0→0.5, n = 14) and an AD group (CDR 0.5→0.5/1, n = 51). We measured the CC area on the midsagittal plane and calculated the atrophy rate between 2 or more visits. The correlation between the CC atrophy rate and annualized Mini Mental State Examination (MMSE) change was also analyzed.
The results indicated that the baseline CC area was larger in the healthy control group compared to the AD group, whereas the CC atrophy rate was higher in the AD group relative to the control and decliner groups. The CC atrophy rate was also correlated with the annualized MMSE change in AD patients (p < 0.05).
Callosal atrophy is present even in early AD and subsequently accelerates, such that the rate of CC atrophy is associated with cognitive decline in AD patients.
我们研究了早期阿尔茨海默病（AD）患者胼胝体（CC）萎缩率及其与认知功能减退的关系。
我们使用了公开可用的纵向MRI数据，这些数据来自137名根据临床痴呆评定量表（CDR）评分进行特征描述的受试者的2次或更多次随访。我们根据认知状态的进展将这些受试者分为3组：健康对照组（CDR 0→0，n = 72）、衰退组（CDR 0→0.5，n = 14）和AD组（CDR 0.5→0.5/1，n = 51）。我们在矢状中面上测量CC面积，并计算2次或更多次随访之间的萎缩率。还分析了CC萎缩率与年化简易精神状态检查表（MMSE）变化之间的相关性。
结果表明，健康对照组的基线CC面积大于AD组，而AD组的CC萎缩率相对于对照组和衰退组更高。AD患者的CC萎缩率也与年化MMSE变化相关（p < 0.05）。
即使在早期AD中也存在胼胝体萎缩，随后会加速，因此CC萎缩率与AD患者的认知功能减退有关。
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