Willms B
MMW Munch Med Wochenschr. 1975 Oct 10;117(41):1655-60.
The antigenicity of insulin is the cause of the side effects of insulin therapy such as insulin allergy, lipoatrophy at the site of injection and insulin resistance. Factors inherent in the individual patient are decisive for the antigenicity of insulin, as well as species specificity of the insulin,purity and galenical form. Clinical aspects and possibilities for treatment of insulin allergy, lipoatrophy and insulin resistance are discussed in relation to our own cases.
胰岛素的抗原性是胰岛素治疗副作用的原因，如胰岛素过敏、注射部位脂肪萎缩和胰岛素抵抗。个体患者自身的因素以及胰岛素的物种特异性、纯度和药剂形式对胰岛素的抗原性起决定性作用。结合我们自己的病例，讨论了胰岛素过敏、脂肪萎缩和胰岛素抵抗的临床情况及治疗可能性。
