拉链相互作用激酶（ZIPK）：功能与信号转导。

Zipper interacting protein kinase (ZIPK): function and signaling.

机构信息

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 Bancho 35-1, Towada, Aomori, 034-8628, Japan.

出版信息

Apoptosis. 2014 Feb;19(2):387-91. doi: 10.1007/s10495-013-0934-3.

DOI:10.1007/s10495-013-0934-3

PMID:24193917

Abstract

Zipper interacting protein kinase (ZIPK), also known as death associated protein kinase 3, is a serine/threonine kinase that mediates variety of cell functions. The major biologic function of ZIPK is considered to be the regulation of apoptosis and smooth muscle contraction. Recently, several other functions of ZIPK have been gradually clarified. In this review article, we summarized the recent findings on ZIPK function and ZIPK-related cell signaling. We propose that ZIPK is a potential future target for the development of pharmaceutical therapy for cancer as well as cardiovascular diseases.

摘要

拉链相互作用激酶（ZIPK），也称为凋亡相关蛋白激酶 3，是一种丝氨酸/苏氨酸激酶，介导多种细胞功能。ZIPK 的主要生物学功能被认为是调节细胞凋亡和平滑肌收缩。最近，ZIPK 的其他一些功能也逐渐被阐明。在这篇综述文章中，我们总结了 ZIPK 功能和 ZIPK 相关细胞信号转导的最新发现。我们提出，ZIPK 是开发癌症和心血管疾病药物治疗的潜在未来靶点。