HHV-6A 和 HHV-6B 被分类为两种不同的病毒。
Classification of HHV-6A and HHV-6B as distinct viruses.
机构信息
HHV-6 Foundation, Santa Barbara, USA,
出版信息
Arch Virol. 2014 May;159(5):863-70. doi: 10.1007/s00705-013-1902-5. Epub 2013 Nov 6.
Abstract
Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.
摘要
人类疱疹病毒 6 型（HHV-6）发现后不久，便鉴定出两种不同的变体，即 HHV-6A 和 HHV-6B。2012 年，国际病毒分类委员会（ICTV）将 HHV-6A 和 HHV-6B 归类为两种不同的病毒。本综述概述了 HHV-6A 和 HHV-6B 之间已记录的几种流行病学、生物学和免疫学差异，这些差异支持 ICTV 的分类。现在需要使用针对特定病毒的临床和实验室检测方法来区分 HHV-6A 和 HHV-6B。为了明确 HHV-6A 和 HHV-6B 之间的生物学和临床差异，本文敦促科学家和医生在今后的所有出版物中尽可能仔细地区分 HHV-6A 和 HHV-6B。
相似文献
1
Classification of HHV-6A and HHV-6B as distinct viruses.
Arch Virol. 2014 May;159(5):863-70. doi: 10.1007/s00705-013-1902-5. Epub 2013 Nov 6.
2
Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7).
J Med Virol. 2016 Dec;88(12):2038-2043. doi: 10.1002/jmv.24561. Epub 2016 May 30.
3
Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression That Correlates with an Increased Antibody Immune Response.
J Virol. 2019 Dec 12;94(1). doi: 10.1128/JVI.01418-19.
4
Prevalence of human herpesvirus 6A and 6B during pregnancy.
Acta Microbiol Immunol Hung. 2014 Sep;61(3):309-16. doi: 10.1556/AMicr.61.2014.3.5.
5
Summary of the 10th International Conference on Human Herpesviruses-6 and -7 (HHV-6A, -6B, and HHV-7).
J Med Virol. 2018 Apr;90(4):625-630. doi: 10.1002/jmv.25004. Epub 2018 Jan 4.
6
Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology.
J Clin Virol. 2006 Mar;35(3):257-63. doi: 10.1016/j.jcv.2005.08.002. Epub 2005 Sep 23.
7
A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.
J Virol. 2017 Apr 13;91(9). doi: 10.1128/JVI.02463-16. Print 2017 May 1.
8
Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains.
J Virol. 2018 Apr 27;92(10). doi: 10.1128/JVI.00135-18. Print 2018 May 15.
9
Glycoproteins of HHV-6A and HHV-6B.
Adv Exp Med Biol. 2018;1045:145-165. doi: 10.1007/978-981-10-7230-7_8.
10
Development of real-time RT-PCR assays for detection of three classes of HHV-6A gene transcripts.
J Med Virol. 2017 Oct;89(10):1830-1836. doi: 10.1002/jmv.24862. Epub 2017 Jun 15.
引用本文的文献
1
Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis.
Front Immunol. 2025 Jul 31;16:1615359. doi: 10.3389/fimmu.2025.1615359. eCollection 2025.
2
Nogo-A and NfL Levels in CSF from Newly Diagnosed Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder Patients Positive for Anti-HHV6-A IgG Autoantibody.
J Clin Med. 2025 Aug 5;14(15):5497. doi: 10.3390/jcm14155497.
3
Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition.
PLoS Pathog. 2025 Jul 9;21(7):e1013300. doi: 10.1371/journal.ppat.1013300. eCollection 2025 Jul.
4
Herpesvirus initiation of dementias and autoimmune diseases.
J Neurovirol. 2025 Jul 7. doi: 10.1007/s13365-025-01265-8.
5
Viral infection and thyroid disorders: a narrative review.
Front Microbiol. 2025 Jun 13;16:1625179. doi: 10.3389/fmicb.2025.1625179. eCollection 2025.
6
CD317 functions as a key antiviral factor in human herpesvirus 6 (HHV-6) infection.
J Virol. 2025 Jul 22;99(7):e0084125. doi: 10.1128/jvi.00841-25. Epub 2025 Jun 24.
7
Rapid diagnosis of ocular viral infections via single-virus detection using solid-state nanopore: A diagnostic evaluation study.
PNAS Nexus. 2025 May 21;4(6):pgaf161. doi: 10.1093/pnasnexus/pgaf161. eCollection 2025 Jun.
8
Human Herpesvirus-6 Infectious Meningitis With Lymphadenitis in an Immunocompetent Adult.
Brain Behav. 2025 Jun;15(6):e70590. doi: 10.1002/brb3.70590.
9
HSV-1 infection induces a downstream shift of the +1 nucleosome.
J Virol. 2025 Apr 15;99(4):e0208624. doi: 10.1128/jvi.02086-24. Epub 2025 Mar 25.
10
Human Herpesvirus 6A Infection-Associated Acute Anterior Uveitis.
J Inflamm Res. 2024 Dec 24;17:11577-11585. doi: 10.2147/JIR.S489178. eCollection 2024.
本文引用的文献
1
Immunomodulation and immunosuppression by human herpesvirus 6A and 6B.
Future Virol. 2013 Mar;8(3):273-287. doi: 10.2217/fvl.13.7.
2
CD134 is a cellular receptor specific for human herpesvirus-6B entry.
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9096-9. doi: 10.1073/pnas.1305187110. Epub 2013 May 14.
3
Activation of CCR2+ human proinflammatory monocytes by human herpesvirus-6B chemokine N-terminal peptide.
J Gen Virol. 2013 Jul;94(Pt 7):1624-1635. doi: 10.1099/vir.0.050153-0. Epub 2013 Mar 27.
4
Calibrated real-time polymerase chain reaction for specific quantitation of HHV-6A and HHV-6B in clinical samples.
J Virol Methods. 2013 Apr;189(1):172-9. doi: 10.1016/j.jviromet.2013.01.018. Epub 2013 Feb 4.
5
Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization.
PLoS Pathog. 2013 Jan;9(1):e1003138. doi: 10.1371/journal.ppat.1003138. Epub 2013 Jan 31.
6
Quantitative analysis of human herpesvirus-6 genome in blood and bone marrow samples from Tunisian patients with acute leukemia: a follow-up study.
Infect Agent Cancer. 2012 Nov 12;7(1):31. doi: 10.1186/1750-9378-7-31.
7
No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome.
Am J Transl Res. 2012;4(4):443-51. Epub 2012 Oct 10.
8
Features of Human Herpesvirus-6A and -6B Entry.
Adv Virol. 2012;2012:384069. doi: 10.1155/2012/384069. Epub 2012 Oct 23.
9
Relationship between beta-herpesviruses reactivation and development of complications after autologous peripheral blood stem cell transplantation.
J Med Virol. 2012 Dec;84(12):1953-60. doi: 10.1002/jmv.23412.
10
Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto's thyroiditis.
PLoS Pathog. 2012;8(10):e1002951. doi: 10.1371/journal.ppat.1002951. Epub 2012 Oct 4.
Zotero 插件