Xie Yu, Zhang Chenrui, Ma Mingchi, Yin Ziqian, Chen Liqian, Yang Yimiao, Wu Shuang, Fan Yuanteng, Xu Yan, He Dan
Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Brain Behav. 2025 Jun;15(6):e70590. doi: 10.1002/brb3.70590.
Human Herpesvirus 6 (HHV-6) infections are primarily observed in immunocompromised individuals, such as those with acquired immunodeficiency syndrome or organ transplant recipients. However, its role as a pathogen in immunocompetent adults remains debated. We aimed to explore the clinical significance of HHV-6 in immunocompetent individuals by presenting a case of HHV-6-associated meningitis with concurrent lymphadenitis.
We describe a case of an immunocompetent adult presenting with recurrent fever and headaches.
Diagnostic evaluations included next-generation sequencing analysis identified HHV-6 in both cerebrospinal fluid specimens and lymphoid tissue samples. The patient demonstrated complete clinical resolution following a 14-day course of ganciclovir therapy.
This case underscores the need to consider HHV-6 infection in immunocompetent adults presenting with meningitis of unknown etiology. Early detection and targeted antiviral therapy may lead to favorable clinical outcomes.
人疱疹病毒6型（HHV-6）感染主要见于免疫功能低下的个体，如获得性免疫缺陷综合征患者或器官移植受者。然而，其在免疫功能正常的成年人中作为病原体的作用仍存在争议。我们旨在通过报告一例HHV-6相关脑膜炎并发淋巴结炎的病例，探讨HHV-6在免疫功能正常个体中的临床意义。
我们描述了一例免疫功能正常的成年人出现反复发热和头痛的病例。
诊断评估包括下一代测序分析，在脑脊液标本和淋巴组织样本中均检测到HHV-6。患者在接受14天的更昔洛韦治疗后临床症状完全缓解。
该病例强调，对于病因不明的脑膜炎免疫功能正常的成年人，需要考虑HHV-6感染。早期检测和针对性抗病毒治疗可能带来良好的临床结果。
