Ma Huiling, Wang Xinyun, Chen Ying, Zhang Yun, Ren Weina, Sheng Yan
Department of Ophthalmology, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310003, People's Republic of China.
Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang Province, 310000, People's Republic of China.
J Inflamm Res. 2024 Dec 24;17:11577-11585. doi: 10.2147/JIR.S489178. eCollection 2024.
Human herpesvirus 6 (HHV-6) infection can cause ophthalmic diseases in immunocompetent patients, recipients of bone marrow transplants, and patients with acquired immunodeficiency syndrome (AIDS). This study describes the case of a healthy 37-year-old male who presented with unilateral anterior uveitis (AU), significant anterior chamber exudation, pupillary membrane closure, increased intraocular pressure, and eyelid edema. Notably, HHV-6A was the only pathogenic agent identified in the blood and aqueous humor. The patient was treated with foscarnet sodium and ganciclovir, showing effective results. Additionally, based on the literature review, the hypothesized mechanism underlying HHV-6A-associated AU was discussed. To the best of our knowledge, this is the first case report of HHV-6A involvement in ocular inflammation and may provide a theoretical basis for further investigations of occurrences of HHV-6A-associated acute AU in clinical settings.
人类疱疹病毒6型（HHV-6）感染可在免疫功能正常的患者、骨髓移植受者以及获得性免疫缺陷综合征（AIDS）患者中引发眼部疾病。本研究描述了一名37岁健康男性的病例，该患者出现单侧前葡萄膜炎（AU）、大量前房渗出、瞳孔膜闭、眼压升高及眼睑水肿。值得注意的是，血液和房水中鉴定出的唯一病原体是HHV-6A。患者接受了膦甲酸钠和更昔洛韦治疗，效果显著。此外，基于文献综述，还讨论了HHV-6A相关AU的潜在机制。据我们所知，这是HHV-6A累及眼部炎症的首例病例报告，可能为临床环境中HHV-6A相关急性AU的发生情况的进一步研究提供理论依据。
