补锌对坦桑尼亚急性肺炎住院时间的影响。
Effect of zinc supplementation on duration of hospitalization in Tanzanian children presenting with acute pneumonia.
机构信息
Department of Pediatrics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
出版信息
J Trop Pediatr. 2014 Apr;60(2):104-11. doi: 10.1093/tropej/fmt089. Epub 2013 Nov 5.
BACKGROUND
Zinc supplementation prevents incident pneumonia in children; however, the effect for pneumonia treatment remains unclear.
METHODS
A randomized, double-blind, placebo-controlled trial of zinc supplements (daily 25 mg) adjunct to antibiotic treatment of radiology-confirmed acute pneumonia was conducted among hospitalized children (6-36 months) in Dar es Salaam, Tanzania.
RESULTS
The trial was stopped early due to low enrollment, primarily owing to exclusion of children outside the age range and >3 days of prior illness. Among children enrolled (n = 94), zinc supplementation indicated no beneficial effect on the duration of hospitalization (IRR: 0.69; 95% CI 0.45-1.06; p = 0.09) or the proportion of children who were hospitalized for <3 days (RR: 0.85; 95% CI: 0.57-1.25; p = 0.40) or <5 days (RR: 1.01; 95% CI: 0.83-1.23; p = 0.92) (IRRs and RRs >1.0 favor zinc).
CONCLUSIONS
Although underpowered, this randomized trial provided no evidence for a beneficial effect of zinc supplementation adjunct to antibiotics for hospitalized children.
背景
补锌可预防儿童发生肺炎；然而，补锌对肺炎治疗的效果尚不清楚。
方法
在坦桑尼亚达累斯萨拉姆，对因影像学确诊的急性肺炎而住院的儿童（6-36 个月）进行了一项随机、双盲、安慰剂对照的锌补充剂（每日 25 毫克）辅助抗生素治疗的试验。
结果
由于入组人数较少，主要是由于排除了年龄范围之外和发病前 >3 天的儿童，该试验提前停止。在入组的儿童中（n=94），补锌对住院时间（IRR：0.69；95%CI：0.45-1.06；p=0.09）或住院 <3 天（RR：0.85；95%CI：0.57-1.25；p=0.40）或 <5 天（RR：1.01；95%CI：0.83-1.23；p=0.92）的儿童比例均无有益影响（IRR 和 RR>1.0 表示锌有利）。
结论
尽管该随机试验的效力不足，但并未提供补锌辅助抗生素治疗住院儿童有益的证据。
Zotero 插件