Jacobsen N, Jonsen J
Pathol Eur. 1975;10(2):115-21.
Incorporation of strontium, lead and nickel radioisotopes was studied in mouse calvaria in tissue culture. About 90% of the incorporated strontium and 5-12% of the lead were recovered in the mineral phase of the calvaria (hot acid soluble fraction), whereas the nickel was recovered mainly in the organic phase (hot alkali soluble fraction). Metabolic inhibition enhanced the incorporation, which indicated that the mineral metabolism of the calvaria comprised ionic exchange or secondary mineralization phenomenons independent of the activity of bone cells but, possibly, guided by a metabolically active bone membrane.
在组织培养中研究了锶、铅和镍放射性同位素在小鼠颅骨中的掺入情况。掺入的锶约90%以及5 - 12%的铅在颅骨的矿质相中被回收（热酸溶性部分），而镍主要在有机相中被回收（热碱溶性部分）。代谢抑制增强了掺入，这表明颅骨的矿质代谢包括离子交换或次生矿化现象，这些现象独立于骨细胞的活性，但可能由代谢活跃的骨膜引导。
