Jacobsen N, Alfheim I, Jonsen J
Res Commun Chem Pathol Pharmacol. 1978 Jun;20(3):571-84.
Radioactive isotopes of strontium or nickel (89Sr and 63Ni) were injected ip as chlorides on adult female mice and the distribution and retention studied in several soft and hard tissues, including tissues of fetuses and sucklings. The strontium concentration was comparable in liver, kidney and heart and higher than that of brain tissue. The acid soluble part of the mineralized tissues showed a strontium concentration 100-1000 times that of the soft tissues. Progeny receiving strontium through placenta or through mammary glands showed a distribution pattern similar to that of their mother, with retention of strontium in mineralized tissue. The nickel concentration was larger in the kidney than in other organs investigated. No nickel affinity was found for mineralized tissues. Nickel was readily passed through placenta and mammary glands. Contrary to findings for strontium, the nickel concentration in tissues of fetuses was higher than that of their mother.
将锶或镍的放射性同位素（89Sr和63Ni）以氯化物形式腹腔注射给成年雌性小鼠，并研究其在包括胎儿和哺乳期幼崽组织在内的几种软组织和硬组织中的分布和滞留情况。肝脏、肾脏和心脏中的锶浓度相当，且高于脑组织中的浓度。矿化组织的酸溶性部分显示锶浓度是软组织的100 - 1000倍。通过胎盘或乳腺接受锶的后代显示出与母亲相似的分布模式，锶滞留在矿化组织中。肾脏中的镍浓度高于所研究的其他器官。未发现镍对矿化组织有亲和力。镍很容易通过胎盘和乳腺。与锶的研究结果相反，胎儿组织中的镍浓度高于其母亲。
