Offenbartl K, Christensen P, Gullstrand P, Prellner K, Seger R A
J Surg Res. 1986 Mar;40(3):198-201. doi: 10.1016/0022-4804(86)90151-4.
A rat model was used to evaluate the possible effect on experimental postsplenectomy sepsis of a human gamma-globulin preparation for intravenous use (Sandoglobulin). Sixty splenectomized male Sprague-Dawley rats were given 3 X 10(3) Streptococcus pneumoniae type 1 intravenously. Twelve of the animals received no treatment and all died, in contrast to 12 sham-operated controls which all survived the challenge. The remaining splenectomized rats were divided into four groups, each consisting of 12 animals. One group was given 120 mg human gamma-globulin twice intraperitoneally (0.3 g/kg body wt), at 18 and 42 hr, after challenge; 10 of the 12 survived, in contrast to none of the 12 in the second group receiving 120 mg human albumin instead of gamma-globulin (P = 0.00003). When the injections were delayed to 24 and 48 hr, 9/12 gamma-globulin-treated animals still survived, in contrast to 0/12 in the albumin group. These findings point to new possibilities for treatment and perhaps prevention of overwhelming postsplenectomy sepsis by administration of high doses of gamma-globulins.
采用大鼠模型评估静脉用人γ球蛋白制剂（Sandoglobulin）对实验性脾切除术后败血症的可能影响。60只脾切除的雄性Sprague-Dawley大鼠静脉注射3×10³ 1型肺炎链球菌。12只动物未接受治疗，全部死亡，而12只假手术对照组在接受挑战后全部存活。其余脾切除的大鼠分为四组，每组12只动物。一组在接受挑战后的18小时和42小时经腹腔给予两次120mg人γ球蛋白（0.3g/kg体重）；12只中有10只存活，而接受120mg人白蛋白而非γ球蛋白的第二组12只动物无一存活（P = 0.00003）。当注射时间延迟至24小时和48小时时，接受γ球蛋白治疗的动物中有9/12存活，而白蛋白组为0/12。这些发现指出了通过给予高剂量γ球蛋白治疗甚至预防严重脾切除术后败血症的新可能性。
