Offenbartl K, Christensen P, Gullstrand P, Prellner K
Infection. 1986 Jul-Aug;14(4):167-9. doi: 10.1007/BF01645256.
Failure to clear the blood of pneumococci after splenectomy may be corrected by active immunization, but some patients show poor antibody response to pneumococcal vaccination. Long-term antibiotic prophylaxis against post-splenectomy sepsis carries the risk of development of bacterial resistance and low patient compliance. In the present study, using a rat model for post-splenectomy sepsis, human immunoglobulin was given 24 h before challenging the animals with 10(3) Streptococcus pneumoniae. Immunoglobulin at a dosage of 300 mg/kg body weight was protective. Reducing the immunoglobulin dose to 75 mg/kg did not alter the mortality rate but significantly prolonged the survival time. The results indicate that the new immunoglobulin preparations for intravenous use might provide an effective means of reducing the risk of post-splenectomy sepsis, even in the most susceptible patients.
脾切除术后未能清除血液中的肺炎球菌可通过主动免疫来纠正，但一些患者对肺炎球菌疫苗接种的抗体反应较差。长期使用抗生素预防脾切除术后败血症存在细菌耐药性发展和患者依从性低的风险。在本研究中，使用脾切除术后败血症的大鼠模型，在给动物注射10³ 肺炎链球菌之前24小时给予人免疫球蛋白。剂量为300mg/kg体重的免疫球蛋白具有保护作用。将免疫球蛋白剂量降至75mg/kg不会改变死亡率，但会显著延长存活时间。结果表明，新的静脉用人免疫球蛋白制剂可能提供一种有效的手段来降低脾切除术后败血症的风险，即使是在最易感的患者中。
