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支持“理论”死后再分布因子（ ）的分析数据：一种评估死后再分布的新模型。

Analytical data supporting the "theoretical" postmortem redistribution factor ( ): a new model to evaluate postmortem redistribution.

作者信息

McIntyre Iain M

机构信息

Forensic Toxicology Laboratory, Department of the Medical Examiner, San Diego, CA, USA.

出版信息

Forensic Sci Res. 2016 Dec 16;1(1):33-37. doi: 10.1080/20961790.2016.1253255. eCollection 2016.

DOI:10.1080/20961790.2016.1253255
PMID:30483608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6197142/
Abstract

The concepts of postmortem redistribution (PMR, ) factor, and "theoretical" PMR ( ) - based upon a drug's characteristic L/P ratio - have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. This paper applies recent data describing liver/peripheral blood (L/P) ratios for many commonly detected drugs to assess these models, and provide a ranking of drugs' propensity for (and degree of) PMR.

摘要

尸检再分布（PMR）因子以及基于药物特征肝/血（L/P）比值的“理论”PMR的概念已被定义，以表达尸检外周血与相应生前全血浓度之间的直接关系。本文应用近期描述多种常见检测药物的肝/外周血（L/P）比值的数据来评估这些模型，并对药物发生PMR的倾向（及程度）进行排名。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f79b/6197142/44e3f462c811/TFSR_A_1253255_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f79b/6197142/44e3f462c811/TFSR_A_1253255_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f79b/6197142/44e3f462c811/TFSR_A_1253255_F0001_OC.jpg

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Forensic Sci Med Pathol. 2014 Mar;10(1):91-6. doi: 10.1007/s12024-013-9503-x. Epub 2013 Nov 7.
3
Hydroxyzine distribution in postmortem cases and potential for redistribution.
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J Anal Toxicol. 2023 Jul 22;47(6):547-551. doi: 10.1093/jat/bkad026.
4
Interpol review of toxicology 2016-2019.国际刑警组织2016 - 2019年毒理学综述
Forensic Sci Int Synerg. 2020 May 23;2:563-607. doi: 10.1016/j.fsisyn.2020.01.018. eCollection 2020.
羟嗪在尸检案例中的分布和重新分布的可能性。
Forensic Sci Int. 2013 Sep 10;231(1-3):28-33. doi: 10.1016/j.forsciint.2013.04.013. Epub 2013 May 10.
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Antemortem and postmortem fentanyl concentrations: a case report.
Int J Legal Med. 2014 Jan;128(1):65-7. doi: 10.1007/s00414-013-0897-5. Epub 2013 Jul 24.
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J Anal Toxicol. 2013 Jul-Aug;37(6):386-9. doi: 10.1093/jat/bkt040. Epub 2013 May 29.
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