McIntyre Iain M
Forensic Toxicology Laboratory, Department of the Medical Examiner, San Diego, CA, USA.
Forensic Sci Res. 2016 Dec 16;1(1):33-37. doi: 10.1080/20961790.2016.1253255. eCollection 2016.
The concepts of postmortem redistribution (PMR, ) factor, and "theoretical" PMR ( ) - based upon a drug's characteristic L/P ratio - have been defined to express the direct relationship between postmortem peripheral blood and the corresponding antemortem whole-blood concentration. This paper applies recent data describing liver/peripheral blood (L/P) ratios for many commonly detected drugs to assess these models, and provide a ranking of drugs' propensity for (and degree of) PMR.
尸检再分布(PMR)因子以及基于药物特征肝/血(L/P)比值的“理论”PMR的概念已被定义,以表达尸检外周血与相应生前全血浓度之间的直接关系。本文应用近期描述多种常见检测药物的肝/外周血(L/P)比值的数据来评估这些模型,并对药物发生PMR的倾向(及程度)进行排名。