Solanki Abhishek A, Liauw Stanley L
Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, IL, USA.
Open Access J Urol. 2011 Jun 15;3:95-104. doi: 10.2147/OAJU.S14245.
Brachytherapy and external beam radiotherapy are effective and commonly used treatment modalities in men with localized prostate cancer. In this review, we explore the role of radiation therapy in the curative management of prostate cancer, including the use of conformal therapeutic techniques to allow for the escalation of radiation doses to tumor, along with the use of combined radiation and hormonal therapy to enhance disease outcomes in men with aggressive disease. We also review the possible anticancer role of HMG-CoA reductase inhibiting agents (statins) in men with prostate cancer. Laboratory evidence suggests that statins may have antineoplastic effects when used alone and may sensitize cells to radiation therapy when given in combination. We explore the biologic basis for an anticancer effect and the clinical evidence suggesting statins may aid in improving outcomes with radiation therapy for localized prostate cancer.
近距离放射治疗和外照射放疗是局限性前列腺癌男性患者常用且有效的治疗方式。在本综述中，我们探讨放射治疗在前列腺癌根治性治疗中的作用，包括使用适形治疗技术以提高肿瘤的放射剂量，以及联合使用放射治疗和激素治疗以改善侵袭性疾病男性患者的疾病转归。我们还综述了HMG-CoA还原酶抑制剂（他汀类药物）在前列腺癌男性患者中可能的抗癌作用。实验室证据表明，他汀类药物单独使用时可能具有抗肿瘤作用，联合使用时可能使细胞对放射治疗敏感。我们探讨了抗癌作用的生物学基础以及提示他汀类药物可能有助于改善局限性前列腺癌放射治疗效果的临床证据。
