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绒毛取样会改变孕妇血清甲胎蛋白水平。

Chorionic villi sampling changes maternal serum alpha-fetoprotein.

作者信息

Mariona F G, Bhatia R, Syner F N, Koppitch F

出版信息

Prenat Diagn. 1986 Jan-Feb;6(1):69-73. doi: 10.1002/pd.1970060110.

DOI:10.1002/pd.1970060110
PMID:2419892
Abstract

Second trimester amniocentesis has traditionally been utilized for prenatal genetic diagnosis. Chorionic villi sampling (CVS) is presently offered as an alternative. The occurrence of fetomaternal bleed (FMB) during CVS could increase the rate of post sampling abortion and, additionally, be of significance in patients at risk for isoimmunization. Detection and quantitation of FMB can be accomplished by the determination of changes in maternal serum alpha-fetoprotein (MSAFP) before and after CVS.

摘要

传统上，孕中期羊膜穿刺术一直用于产前基因诊断。目前，绒毛取样（CVS）可作为一种替代方法。绒毛取样过程中母胎出血（FMB）的发生可能会增加取样后流产的几率，此外，对于有血型同种免疫风险的患者也具有重要意义。母胎出血的检测和定量可以通过测定绒毛取样前后母血清甲胎蛋白（MSAFP）的变化来完成。

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Noninvasive prenatal aneuploidy testing of chromosomes 13, 18, 21, X, and Y, using targeted sequencing of polymorphic loci.应用多态性位点靶向测序的无创性产前染色体 13、18、21、X 和 Y 非整倍体检测。
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Feto-maternal transfusion after chorionic villus sampling. Evaluation by maternal serum alphafetoprotein measurement.绒毛取样后的母胎输血。通过母体血清甲胎蛋白测量进行评估。
Hum Genet. 1988 Jan;78(1):83-5. doi: 10.1007/BF00291241.

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