Richard J L, Warnet J M, Ducimetière P
Rev Epidemiol Sante Publique. 1985;33(4-5):347-51.
Serum proteins and their electrophoretic fractions: albumin-alpha-1 globulin (Alb-alpha-1), alpha-2 and alpha-3 globulins, beta and gamma globulins have been included in the Paris Prospective Study which has concerned 7434 middle-aged men free of any atherosclerotic disease at entry and followed-up during 6.6 years on average. The level of Alb-alpha-1 is significantly lower among myocardial infarction or sudden death cases: the mean difference with controls is equal to one gram. The inverse relationship between incidence and Alb-alpha-1 level is a continuous one. No relationship is observed with angina. In multivariate analysis, serum cholesterol, blood pressure, tobacco and Alb-alpha-1 (negative relationship) are significantly associated with grave coronary heart disease. The relationship with Alb-alpha-1 is independent of the hematocrit. Possible pathogenic mechanisms are discussed.
白蛋白-α1球蛋白（Alb-α1）、α2和α3球蛋白、β球蛋白和γ球蛋白已纳入巴黎前瞻性研究，该研究涉及7434名中年男性，这些男性在入组时无任何动脉粥样硬化疾病，平均随访6.6年。心肌梗死或猝死病例中Alb-α1水平显著较低：与对照组的平均差异等于1克。发病率与Alb-α1水平呈持续的负相关关系。未观察到与心绞痛有关联。在多变量分析中，血清胆固醇、血压、吸烟和Alb-α1（负相关关系）与严重冠心病显著相关。与Alb-α1的关系独立于血细胞比容。文中讨论了可能的致病机制。
