Salehi Rezvanie, Enamzadeh Elgar, Goldust Mohamad
Tabriz University of Medical Sciences, Tabriz, Iran.
Pak J Biol Sci. 2013 Jan 1;16(1):44-7. doi: 10.3923/pjbs.2013.44.47.
Atrial fibrillation is associated with cerebral stroke, congestive heart insufficiency and mortality. The present study aimed at evaluating of cognitive disorders in patients with history of atrial fibrillation without cerebral stroke. In a case-control study, 100 patients with first-ever atrial fibrillation seizure without history of cerebral stroke were evaluated. One hundred healthy subjects with normal sinus rhythm matched with the patients in terms of age and gender were regarded as the control group. The case and control groups were followed up for at least one year after occurring of atrial fibrillation. Cognitive disorders were evaluated at the last visit. The case group was consisted of 51 men and 42 women with mean age of 71.08 +/- 5.35 years and there were 53 men and 43 women with mean age of 71.34 +/- 5.04 years in the control group. Previous history of hypertension, diabetes mellitus, hyperlipidemia, hypercholesterolemia, smoking, consuming of alcohol and warfarin in the case group were 49.5, 23.7, 18.3, 31.2, 14, 7.5 and 9.7% and in the control group 6.4, 35.4, 24, 36.5, 21.9, 13.5 and 12.5%, respectively. In this regard, there was not statistically meaningful difference between these two groups. Dementia was detected in 3 (3.2%) of the case and 1 (1%) of the control group subjects (p = 0.29). Comparing two groups with and without dementia demonstrated that there was not any meaningful risk factor. According to the results, dementia in patients with positive history of atrial fibrillation was more than normal population.
心房颤动与脑卒、充血性心力衰竭及死亡率相关。本研究旨在评估无脑卒中病史的心房颤动患者的认知障碍情况。在一项病例对照研究中，对100例首次发生心房颤动且无脑卒中病史的患者进行了评估。将100例年龄和性别与患者匹配的窦性心律正常的健康受试者作为对照组。心房颤动发生后，对病例组和对照组至少随访一年。在最后一次随访时评估认知障碍情况。病例组由51名男性和42名女性组成，平均年龄为71.08±5.35岁；对照组有53名男性和43名女性，平均年龄为71.34±5.04岁。病例组中高血压、糖尿病、高脂血症、高胆固醇血症、吸烟、饮酒及服用华法林的既往史分别为49.5%、23.7%、18.3%、31.2%、14%、7.5%和9.7%，对照组分别为6.4%、35.4%、24%、36.5%、21.9%、13.5%和12.5%。在这方面，两组之间无统计学意义上的差异。病例组中有3名（3.2%）受试者被检测出患有痴呆，对照组中有1名（1%）受试者患有痴呆（p = 0.29）。比较有痴呆和无痴呆的两组发现，没有任何有意义的危险因素。根据结果，有心房颤动阳性病史的患者中痴呆的发生率高于正常人群。
