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为食管癌患者进行个体化治疗。

Personalizing therapy for esophageal cancer patients.

机构信息

Department of Surgery, Institute for the Treatment of Esophageal and Thoracic Disease, The Western Pennsylvania Hospital, Allegheny Health Network, 4600 Friendship Avenue, Suite 4800, Pittsburgh, PA 15224, USA.

出版信息

Thorac Surg Clin. 2013 Nov;23(4):471-8. doi: 10.1016/j.thorsurg.2013.07.001.

DOI:10.1016/j.thorsurg.2013.07.001
PMID:24199697
Abstract

Management of esophageal cancer starts with accurate tissue diagnosis and clinical staging. Advances in screening and surveillance programs and endoscopic techniques have resulted in patients with early-stage esophageal cancer diagnosed more frequently. Endoscopic mucosal resection for staging is essential to diagnose T1a cancer and crucial to exclude risk factors for progression to cancer or presence of concomitant cancer. Esophagectomy is an essential component of treatment of locally advanced, resectable esophageal cancer. Despite intensive multidisciplinary approaches, the prognosis of esophageal cancer is unacceptable. This article focuses on the process of decision making used to select optimal therapy for esophageal cancer.

摘要

食管癌的治疗始于准确的组织诊断和临床分期。筛查和监测计划以及内镜技术的进步使更多的早期食管癌患者得到诊断。内镜黏膜切除术对分期至关重要,可用于诊断 T1a 期癌症,并有助于排除进展为癌症或同时存在癌症的危险因素。食管癌根治术是局部进展期可切除食管癌治疗的重要组成部分。尽管采用了强化多学科方法,但食管癌的预后仍不理想。本文重点介绍了用于选择食管癌最佳治疗方案的决策过程。

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1
Personalizing therapy for esophageal cancer patients.为食管癌患者进行个体化治疗。
Thorac Surg Clin. 2013 Nov;23(4):471-8. doi: 10.1016/j.thorsurg.2013.07.001.
2
Stage-directed individualized therapy in esophageal cancer.食管癌的导演式个体化治疗。
Ann N Y Acad Sci. 2016 Oct;1381(1):50-65. doi: 10.1111/nyas.13113. Epub 2016 Jul 6.
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Esophageal Adenocarcinoma: Screening, Surveillance, and Management.食管腺癌:筛查、监测和管理。
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Recommendations for Surveillance and Management of Recurrent Esophageal Cancer Following Endoscopic Therapies.内镜治疗后复发食管癌的监测和管理建议。
Surg Clin North Am. 2021 Jun;101(3):415-426. doi: 10.1016/j.suc.2021.03.004.
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[Current diagnosis and therapy of esophageal carcinoma].[食管癌的当前诊断与治疗]
Z Gastroenterol. 2004 Jul;42(7):615-21. doi: 10.1055/s-2004-812790.
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[Diagnosis and treatment of esophageal cancer].[食管癌的诊断与治疗]
Internist (Berl). 2012 Nov;53(11):1315-27; quiz 1328-9. doi: 10.1007/s00108-012-3128-0.
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Endoscopic management of Barrett's esophagus associated dysplasia and early esophageal cancer.巴雷特食管相关异型增生和早期食管癌的内镜治疗
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Evaluation of endoscopic mucosal resection for superficial esophageal carcinoma.内镜下黏膜切除术治疗早期食管癌的评估
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Diagnosis and treatment of early esophageal cancer.早期食管癌的诊断与治疗
Curr Opin Gastroenterol. 2006 Jul;22(4):433-6. doi: 10.1097/01.mog.0000231821.48890.e6.
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Endoscopic ultrasound cannot determine suitability for esophagectomy after aggressive chemoradiotherapy for esophageal cancer.对于接受过食管癌根治性放化疗的患者,内镜超声无法确定其是否适合进行食管切除术。
Am J Gastroenterol. 1999 Apr;94(4):906-12. doi: 10.1111/j.1572-0241.1999.985_h.x.

引用本文的文献

1
Evolution in the Treatment of Esophageal Disease at a Single Academic Institution: 2004-2013.单一学术机构2004 - 2013年食管疾病治疗的进展
J Laparoendosc Adv Surg Tech A. 2017 Sep;27(9):915-923. doi: 10.1089/lap.2017.0069. Epub 2017 May 9.
2
Markers of sarcopenia quantified by computed tomography predict adverse long-term outcome in patients with resected oesophageal or gastro-oesophageal junction cancer.通过计算机断层扫描量化的肌肉减少症标志物可预测接受手术切除的食管癌或胃食管交界癌患者的长期不良预后。
Eur Radiol. 2016 May;26(5):1359-67. doi: 10.1007/s00330-015-3963-1. Epub 2015 Sep 3.