三磷酸腺苷、环磷酸腺苷和镁可增加大鼠纹状体酪氨酸羟化酶对其辅助因子的亲和力。
ATP, cyclic AMP, and magnesium increase the affinity of rat striatal tyrosine hydroxylase for its cofactor.
作者信息
Lovenberg W, Bruckwick E A, Hanbauer I
出版信息
Proc Natl Acad Sci U S A. 1975 Aug;72(8):2955-8. doi: 10.1073/pnas.72.8.2955.
Abstract
Treatment of rat striatal tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] with conditions optimal for protein phosphorylation results in the reduction of the tyrosine hydroxylase Km for the cofactor 6-methyltetrahydropterin from 0.50 mM to 0.16 mM. This reaction is dependent upon ATP, 3':5'-cAMP, and Mg++ and causes a marked decrease in the sensitivity to end-product inhibition. Other brain regions and the adrenal gland show a similar response.
摘要
用最适于蛋白质磷酸化的条件处理大鼠纹状体酪氨酸羟化酶[酪氨酸3-单加氧酶；L-酪氨酸，四氢蝶呤：氧氧化还原酶(3-羟化)；EC 1.14.16.2]，会使该酶对辅因子6-甲基四氢蝶呤的米氏常数（Km）从0.50 mM降至0.16 mM。此反应依赖于ATP、3':5'-环磷酸腺苷(cAMP)和镁离子(Mg++)，并导致对终产物抑制的敏感性显著降低。其他脑区和肾上腺也表现出类似反应。
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