酶促非对称谷氨酸酯的氧鎓叶立德重排。
Oxonium ylide rearrangement of enzymatically desymmetrized glutarates.
机构信息
Department für Chemie, Universität zu Köln , DE-50939 Cologne, Germany.
出版信息
Org Lett. 2013 Dec 6;15(23):5998-6001. doi: 10.1021/ol402887z. Epub 2013 Nov 7.
PMID:24200031
Abstract
The combination of an enzyme-mediated enantioselective desymmetrization of readily available 3-benzyloxyglutarates and subsequent rhodium-catalyzed oxonium ylide rearrangement of their corresponding in situ derived diazo ketones offers a very concise and highly stereoselective access to functionalized tetrahydrofuranone building blocks.
摘要
酶介导的对映选择性去对称化反应，可利用易得的 3-苄氧基戊二酸酯，并随后进行铑催化的原位生成的重氮酮的氧翁叶立德重排，为功能化的四氢呋喃酮砌块提供了非常简洁和高度立体选择性的方法。
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