Department of Radiology, Shandong Provincial Hospital, Shandong University, No. 324, Jingwu Weiqi Road, Jinan, P. R. China 250021.
Acad Radiol. 2013 Dec;20(12):1535-41. doi: 10.1016/j.acra.2013.09.007.
To investigate the relationship between apparent diffusion coefficient (ADC) values and the Ki-67 staining index (Ki-67 SI), a tumor proliferation marker, in prostate cancer (PCa).
Forty-three patients with PCa and thirty-six patients with benign prostatic hyperplasia (BPH) underwent diffusion-weighted (DW) imaging on 3T magnetic resonance (MR) with pelvic phased-array coil. The ADC values of PCa were calculated from two DW images (b = 0, 800 s/mm(2)). Immunohistochemical staining for Ki-67 was used to determine the Ki-67 SI of PCa and BPH. The Pearson correlation test was used to examine the relationship between ADC values and the Ki-67 SI. The ADC values of PCa with different level of Ki-67 SI were compared using an independent-sample t-test.
The mean (±standard deviation [SD]) Ki-67 SI of PCa (7.23 ± 5.29%) was higher than that of BPH (2.11 ± 1.90%) (P < .001). The mean (±SD) ADC value (10(-3) mm(2)/s) of PCa (0.850 ± 0.155) was lower than that of BPH (1.173 ± 0.245) (P < .001). The ADC values of PCa were negatively correlated with the Ki-67 SI (r = -0.459, P = .002). The mean ADC values of PCa with Ki-67 >3.5% and ≤3.5% were (0.803 ± 0.094) and (0.936 ± 0.208), respectively. The former was significantly lower than the latter (P = .031). The ADC values of PCa with Ki-67 >7.1% and ≤7.1% were (0.779 ± 0.081) and (0.906 ± 0.178), respectively. The difference was significant (P = .004).
The ADC values of PCa could reflect the tumor proliferative activity and the differentiated degree of PCa.
探讨前列腺癌（PCa）表观扩散系数（ADC）值与肿瘤增殖标志物 Ki-67 染色指数（Ki-67 SI）之间的关系。
43 例 PCa 患者和 36 例前列腺增生（BPH）患者均行 3T 磁共振（MR）盆腔相控阵线圈弥散加权（DW）成像。在两个 DW 图像（b = 0，800 s/mm2）上计算 PCa 的 ADC 值。采用免疫组化法检测 PCa 和 BPH 的 Ki-67 SI。采用 Pearson 相关检验分析 ADC 值与 Ki-67 SI 的相关性。采用独立样本 t 检验比较不同 Ki-67 SI 水平的 PCa 的 ADC 值。
PCa 的平均（±标准差）Ki-67 SI（7.23±5.29%）高于 BPH（2.11±1.90%）（P＜0.001）。PCa 的平均（±标准差）ADC 值（10-3mm2/s）为 0.850±0.155，低于 BPH 的 1.173±0.245（P＜0.001）。PCa 的 ADC 值与 Ki-67 SI 呈负相关（r=-0.459，P=0.002）。Ki-67＞3.5%和≤3.5%的 PCa 的平均 ADC 值分别为（0.803±0.094）和（0.936±0.208），前者明显低于后者（P=0.031）。Ki-67＞7.1%和≤7.1%的 PCa 的平均 ADC 值分别为（0.779±0.081）和（0.906±0.178），差异有统计学意义（P=0.004）。
PCa 的 ADC 值可反映肿瘤的增殖活性和分化程度。
