Ma Teng, Yang Shaolin, Jing Haiyan, Cong Lin, Cao Zhixin, Liu Zhiling, Huang Zhaoqin
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan City, Shandong Province, China.
Departments of Psychiatry, Radiology and Bioengineering, University of Illinois at Chicago, Chicago, IL, USA.
NMR Biomed. 2018 Mar;31(3). doi: 10.1002/nbm.3884. Epub 2018 Jan 9.
Prostate cancer (PCa) is the second most common cancer in men. The Gleason score (GS) and biomarkers play important roles in the diagnosis and treatment of patients with PCa. The purpose of this study was to investigate the relationship between the apparent diffusion coefficient (ADC) and the molecular markers Ki-67, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in PCa. Thirty-nine patients with 39 lesions, who had been diagnosed with PCa, were enrolled in this study. All patients underwent diffusion-weighted magnetic resonance imaging (DW-MRI) (b = 800 s/mm ). The expression of Ki-67, HIF-1α and VEGF was assessed by immunohistochemistry. Statistical analysis was applied to analyze the association between ADC and prostate-specific antigen (PSA), GS and the expression of Ki-67, HIF-1α and VEGF. The group differences in ADC among different grades of Ki-67, HIF-1α and VEGF were also analyzed. The mean ± standard deviation of ADC was (0.76 ± 0.27) × 10 mm /s. ADC correlated negatively with PSA and GS (p < 0.05). The Ki-67 staining index (SI), HIF-1α expression and VEGF expression in PCa were correlated inversely with ADC, controlling for age (r = -0.332, p < 0.05; r = -0.662, p < 0.0005; and r = -0.714, p < 0.0005, respectively). ADC showed a significant difference among different grades of Ki-67 (F = 9.164, p = 0.005), HIF-1α (F = 40.333, p < 0.0005) and VEGF (F = 22.048, p < 0.0005). In conclusion, ADC was correlated with PSA, GS, and Ki-67, HIF-1α and VEGF expression in patients with PCa. ADC may be used to evaluate tumor proliferation, hypoxia and angiogenesis in PCa.
前列腺癌（PCa）是男性中第二常见的癌症。 Gleason评分（GS）和生物标志物在PCa患者的诊断和治疗中起着重要作用。本研究的目的是探讨表观扩散系数（ADC）与PCa中分子标志物Ki-67、缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）之间的关系。39例患有39个病灶且已被诊断为PCa的患者纳入本研究。所有患者均接受了扩散加权磁共振成像（DW-MRI）（b = 800 s/mm²）。通过免疫组织化学评估Ki-67、HIF-1α和VEGF的表达。应用统计学分析来分析ADC与前列腺特异性抗原（PSA）、GS以及Ki-67、HIF-1α和VEGF表达之间的关联。还分析了不同等级的Ki-67、HIF-1α和VEGF之间ADC的组间差异。ADC的平均值±标准差为（0.76±0.27）×10⁻³mm²/s。ADC与PSA和GS呈负相关（p < 0.05）。在控制年龄的情况下，PCa中Ki-67染色指数（SI）、HIF-1α表达和VEGF表达与ADC呈负相关（r = -0.332，p < 0.05；r = -0.662，p < 0.0005；r = -0.714，p < 0.0005）。ADC在不同等级的Ki-67（F = 9.164，p = 0.00）、HIF-1α（F = 40.333，p < 0.0005）和VEGF（F = 22.048，p < 0.0005）之间存在显著差异。总之，ADC与PCa患者的PSA、GS以及Ki-67、HIF-1α和VEGF表达相关。ADC可用于评估PCa中的肿瘤增殖、缺氧和血管生成。
