Klinikum Bad Hersfeld, Bad Hersfeld, Germany.
Europace. 2014 Mar;16(3):354-62. doi: 10.1093/europace/eut343. Epub 2013 Nov 7.
The general clinical profile of European pacemaker recipients who require predominant ventricular pacing (VP) is scarcely known. We examined the demographic and clinical characteristics of the 1808 participants (out of 1833 randomized patients) of the ongoing Biventricular Pacing for Atrio-ventricular Block to Prevent Cardiac Desynchronization (BioPace) study.
BioPace recruited patients between May 2003 and September 2007 predominantly in European medical centres. We analysed demographic data and described clinical characteristics and electrophysiological parameters prior to device implantation in 1808 enrolled patients. The mean age ± standard deviation (SD) of the 1808 patients was 73.5 ± 9.2 years, 1235 (68%) were men, 654 (36%) presented without structural heart disease, 547 (30%) had ischemic, 355 (20%) hypertensive, 146 (8%) valvular, and 102 (6%) non-ischemic dilated cardiomyopathy. Mean left ventricular ejection fraction was 55.4 ± 12.3%. The main pacing indications were (a) permanent and intermittent atrioventricular (AV) block in 973 (54%), (b) atrial fibrillation with slow ventricular rate in 313 (17%), and (c) miscellaneous bradyarrhythmias in 522 (29%) patients. Mean QRS duration was 118.5 ± 30.5 ms, left bundle branch block was present in 316 (17%), and atrial tachyarrhythmias in 426 (24%) patients.
To the best of our knowledge, this sample is a representative source of description of the general profile of European pacemaker recipients who require predominant VP. Patients' characteristics included advanced age, predominantly male gender, preserved left ventricular systolic function, high-grade AV block, narrow QRS complex, and atrial tachyarrhythmias, the latter being present in nearly one-fourth of the cohort.
欧洲起搏器患者中需要主要心室起搏（VP）的一般临床特征鲜为人知。我们检查了正在进行的双心室起搏用于预防房室传导阻滞的心脏失同步（BioPace）研究的 1808 名参与者（1833 名随机患者）的人口统计学和临床特征。
BioPace 主要在欧洲医疗中心招募 2003 年 5 月至 2007 年 9 月之间的患者。我们分析了 1808 名入组患者的人口统计学数据，并描述了植入前的临床特征和电生理参数。1808 名患者的平均年龄±标准差（SD）为 73.5±9.2 岁，1235 名（68%）为男性，654 名（36%）无结构性心脏病，547 名（30%）为缺血性，355 名（20%）为高血压，146 名（8%）为瓣膜性，102 名（6%）为非缺血性扩张型心肌病。平均左心室射血分数为 55.4±12.3%。主要起搏指征为（a）永久性和间歇性房室（AV）阻滞 973 例（54%），（b）心房颤动伴心室率缓慢 313 例（17%），（c）各种缓慢性心律失常 522 例（29%）。平均 QRS 持续时间为 118.5±30.5ms，316 例（17%）存在左束支传导阻滞，426 例（24%）存在房性心动过速。
据我们所知，这一样本是描述需要主要 VP 的欧洲起搏器患者一般特征的代表性来源。患者特征包括高龄、主要为男性、左心室收缩功能保存良好、高度房室传导阻滞、窄 QRS 波群和房性心动过速，近四分之一的患者存在后者。
