Sugahara Go, Kiuchi Akio, Usui Reiko, Usui Ryouichi, Mineshige Takayuki, Kamiie Junichi, Shirota Kinji
Research Institute of Biosciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
J Vet Med Sci. 2014 Mar;76(3):435-8. doi: 10.1292/jvms.13-0449. Epub 2013 Nov 8.
To the best of our knowledge, we present here the first report of a case involving granulomatous pododermatitis caused by Fusarium proliferatum in a 10-year-old female cat. A cutaneous mass developed on the foot-pad of the right hind leg. Nodular granulomatous dermatitis with numerous macrophages and multinucleated giant cells containing cytoplasmic fungal structures were revealed on histological examination. Periodic acid-Schiff reaction and Fungi-Fluor staining clearly revealed irregular, septate fungal hyphae englobed by macrophages and multinucleated giant cells. Polymerase chain reaction and sequence analysis targeting three domains of the extracted fungal DNA revealed 100% amplicon homology with F. proliferatum.
据我们所知，我们在此首次报告一例10岁雌性猫由层出镰刀菌引起的肉芽肿性足皮炎病例。右后腿脚垫出现一个皮肤肿物。组织学检查显示为结节性肉芽肿性皮炎，有大量巨噬细胞和含有胞质真菌结构的多核巨细胞。过碘酸希夫反应和真菌荧光染色清楚地显示巨噬细胞和多核巨细胞包绕的不规则、有隔膜的真菌菌丝。针对提取的真菌DNA三个区域的聚合酶链反应和序列分析显示，扩增子与层出镰刀菌的同源性为100%。
