Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California 90502, USA.
Proc Am Thorac Soc. 2010 May;7(3):210-5. doi: 10.1513/pats.200906-033AL.
Serious infections due to non-Aspergillus molds are being encountered with increasing frequency. Factors likely responsible for the rise of these infections include aging populations in countries with advanced medical technologies, the resultant increase in incidence of many cancers, increasingly intensive myeloablative therapies for these cancers, increasingly intensive care for critically ill patients, and increases in the frequency of solid organ and hematopoietic stem cell transplantation. Although diagnostic and therapeutic modalities have improved, mortality rates for invasive mold infections remain high. In this review, we summarize current knowledge about non-Aspergillus mold infections of the chest, with a focus on risk factors, clinical features, diagnosis, and treatment.
非曲霉属霉菌引起的严重感染正日益频繁地发生。导致这些感染增加的因素可能包括医疗技术先进的国家人口老龄化、许多癌症发病率的上升、针对这些癌症的强化骨髓清除疗法、对重症患者的强化护理以及实体器官和造血干细胞移植的频率增加。尽管诊断和治疗方法有所改善,但侵袭性霉菌感染的死亡率仍然很高。在这篇综述中,我们总结了目前关于胸部非曲霉属霉菌感染的知识,重点介绍了危险因素、临床特征、诊断和治疗。