Department of Biology, Texas Woman's University, Denton, TX 76204, United States.
Pharmacol Biochem Behav. 2013 Dec;114-115:52-7. doi: 10.1016/j.pbb.2013.10.024. Epub 2013 Nov 4.
The effects of the 5-HT2A/2C receptor antagonist, ketanserin, on lordosis behavior were examined in hormonally primed, ovariectomized Fischer and Sprague-Dawley females. Rats were primed with 0.067μg/g body weight estradiol benzoate and 3.33μg/g body weight progesterone. After a pretest for sexual behavior, rats were injected with 0.416 to 10mg/kg ketanserin. In both strains, lordosis behavior, lordosis quality, and proceptivity were significantly reduced by ketanserin. There was modest evidence of a strain difference with Sprague-Dawley females slightly more sensitive to ketanserin. In a second experiment, the effects of 10mg/kg fluoxetine, 1mg/kg ketanserin, and their combination were examined to determine if the two drugs would have additive effects on sexual behavior. There was no evidence that the drugs were additive in their effect and the strains did not differ in their response to the combined treatment. These findings are discussed in relation to prior evidence for strain differences in the sexual behavioral response to fluoxetine and to a receptor agonist acting preferentially at 5-HT1A receptors.
在激素诱导的去卵巢费希尔和斯普拉格-道利雌性大鼠中，研究了 5-HT2A/2C 受体拮抗剂酮色林对发情行为的影响。大鼠用 0.067μg/g 体重苯甲酸雌二醇和 3.33μg/g 体重孕酮诱导。在性行为预测试验后，大鼠注射 0.416 至 10mg/kg 酮色林。在两种品系中，酮色林显著降低了发情行为、发情质量和求爱性。有适度的证据表明存在品系差异，斯普拉格-道利雌性对酮色林的敏感性略高。在第二项实验中，检查了 10mg/kg 氟西汀、1mg/kg 酮色林及其组合对性行为的影响，以确定这两种药物在其对性行为的影响上是否具有相加作用。没有证据表明这些药物的作用具有相加性，而且两种品系对联合治疗的反应没有差异。这些发现与先前关于氟西汀对性行为反应的品系差异的证据以及对优先作用于 5-HT1A 受体的受体激动剂的证据有关。
