Oncology Department, Central Hospital of Enshi Prefecture, Enshi 445000, Hubei, China.
Oncology Department, Central Hospital of Enshi Prefecture, Enshi 445000, Hubei, China.
Clin Breast Cancer. 2014 Feb;14(1):e10-3. doi: 10.1016/j.clbc.2013.09.007. Epub 2013 Sep 28.
The objective of this study was to explore the effect of conservative surgery plus postoperative axillary radiotherapy without axillary lymph node dissection vs. modified radical mastectomy in patients with stage I breast cancer.
In this study, 186 patients with stage I breast cancer were enrolled. Among them, 98 patients underwent breast-conserving surgery without axillary node dissection. From the first day after surgery, each of them received 6 cycles of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy, and thereafter radical radiotherapy for 5 to 6 weeks. Eighty-eight patients received modified radical mastectomy with postoperative chemotherapy and radiotherapy. The clinical data of these 186 patients were analyzed.
There was no significant difference (P > .05) in local recurrence and survival rates between the conservative plus axillary radiotherapy group and the modified radical mastectomy group, although a significantly greater incidence of upper limb dysfunction and edema were observed in the modified mastectomy group (P < .05).
The efficacy of conservative surgery plus axillary radiotherapy alone is superior to that of axillary node dissection for stage I breast cancer patients.
本研究旨在探讨保乳手术加术后腋窝放疗而不进行腋窝淋巴结清扫与改良根治性乳房切除术在 I 期乳腺癌患者中的疗效。
本研究纳入了 186 例 I 期乳腺癌患者。其中，98 例患者接受了保乳手术而不进行腋窝淋巴结清扫。术后第一天起，每位患者接受 6 个周期的 CMF（环磷酰胺、甲氨蝶呤、5-氟尿嘧啶）化疗，然后进行 5 至 6 周的根治性放疗。88 例患者接受了改良根治性乳房切除术，并在术后进行化疗和放疗。对这 186 例患者的临床资料进行了分析。
保乳加腋窝放疗组与改良根治术组的局部复发率和生存率无显著差异（P>.05），但改良根治术组上肢功能障碍和水肿的发生率明显更高（P<.05）。
保乳手术加腋窝放疗的疗效优于腋窝淋巴结清扫术，适用于 I 期乳腺癌患者。
