A rapid fixation technique of epidermis for electron microscopy.

A rapid processing technique for ultrastructural studies of human epidermis has been devised in order to reduce dislocation of soluble compounds and to make available sections for diagnostic purposes within reasonable time (ca 4 hours). The morphology of cellular components agreed with or improved upon that obtained after commonly used methods. Thus, for example, the substance in the intercorneal space was better preserved and the cytomembrane and certain of its specializations appeared more distinct.