Bruze M, Zimerson E
Acta Derm Venereol. 1985;65(6):548-51.
Thirteen patients with contact allergy to phenol-formaldehyde resins (P-F-R) were patch tested with 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol. Nine patients reacted to at least 1 compound, all giving positive test responses to 2,4-dimethylol phenol. Seven patients reacted simultaneously to 2,6-dimethylol phenol while only 1 patient reacted to 3-methylol phenol. Negative test responses were noted in 20 controls. Chemical investigation by high pressure liquid chromatography indicated that the compounds tested were pure and separable. The 3 reported sensitizers may, theoretically, be generated during the manufacture of P-F-R. 2,4-Dimethylol phenol and 2,6-dimethylol phenol have been demonstrated and there has been chromatographic evidence of 3-methylol phenol in the P-F-R used in the routine test series at the department.
对酚醛树脂（P-F-R）有接触性过敏的13名患者用3-羟甲基苯酚、2,4-二羟甲基苯酚和2,6-二羟甲基苯酚进行了斑贴试验。9名患者对至少1种化合物有反应，均对2,4-二羟甲基苯酚呈阳性试验反应。7名患者同时对2,6-二羟甲基苯酚有反应，而只有1名患者对3-羟甲基苯酚有反应。20名对照者斑贴试验反应为阴性。高压液相色谱法进行的化学分析表明，所测试的化合物是纯的且可分离。理论上，3种已报道的致敏剂可能在酚醛树脂的制造过程中产生。已证实存在2,4-二羟甲基苯酚和2,6-二羟甲基苯酚，并且在该科室常规试验系列所用的酚醛树脂中有3-羟甲基苯酚的色谱证据。
