同时对巯基混合物和巯基苯并噻唑的斑贴试验反应：1994-2008 年北美接触性皮炎组的回顾性分析。

Concomitant patch test reactions to mercapto mix and mercaptobenzothiazole: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008.

机构信息

From the *Department of Dermatology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN; †Department of Dermatology, University of Cincinnati, Cincinnati, OH; ‡Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; §Department of Dermatology, Columbia University, New York, NY; ∥Department of Dermatology, University of California San Francisco, San Francisco, CA; ¶Department of Dermatology, Cleveland Clinic, Cleveland, OH; #Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; **Dartmouth-Hitchcock Medical Center, Lebanon, NH; ††Ohio State University Medical Center, Columbus, OH; ‡‡Department of Dermatology, University of Louisville, Louisville, KY; §§Department of Dermatology, Pennsylvania State University, Philadelphia, PA; ∥∥Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada; and ¶¶Department of Dermatology, Oregon Health Science University, Portland, OR.

出版信息

Dermatitis. 2013 Nov-Dec;24(6):321-7. doi: 10.1097/DER.0b013e3182a8c1ab.

DOI:10.1097/DER.0b013e3182a8c1ab

PMID:24201467

Abstract

BACKGROUND

Mercaptobenzothiazole (MBT) and mercapto compounds are primarily used in rubber products.

OBJECTIVE

This study aimed to examine concomitant-positive rates of MBT (1% pet) and the 4-part mercapto mix (MM) (1% pet).

DESIGN

This is a retrospective cross-sectional data from the North American Contact Dermatitis Group.

RESULTS

A total of 30,880 patients were patch tested to MM and MBT. There were 333 positive reactions to MM and 427 positive reactions to MBT. Ninety-eight patients were positive to MM alone, 192 to MBT alone, and 235 reacted to both. Forty-five percent (192/427) of MBT reactions would have been missed by only testing to MM, and 29% (98/333) of MM reactions would have been missed by testing to MBT alone. Most of these "missed" reactions, however, were doubtful (+/-) or mild (+) (MBT, 65%; MM, 78%), whereas most reactions in patients who reacted to both were moderate (++) and/or strong (+++) (52.3%). Gloves were the most common source.

CONCLUSIONS

Mercaptobenzothiazole is the preferential screening allergen for mercapto compounds because of the following: (1) greater proportion of missed reactions with MM; (2) greater proportion of doubtful/mild reactions in the missed group for MM; and (3) in the group positive to both, the low rate (2%) of moderate/strong reactions to MM and doubtful/mild reactions to MBT as compared with the converse (21%). Mercapto mix may be useful in an auxiliary rubber series.

摘要

背景

巯基苯并噻唑（MBT）和巯基化合物主要用于橡胶制品。

目的

本研究旨在检测 MBT（1% pet）和 4 部分巯基混合物（MM）（1% pet）的同时阳性率。

设计

这是北美接触性皮炎组的回顾性横断面数据。

结果

共有 30880 例患者接受 MM 和 MBT 斑贴试验。MM 有 333 例阳性反应，MBT 有 427 例阳性反应。98 例患者仅对 MM 呈阳性，192 例患者仅对 MBT 呈阳性，235 例患者对两者均呈阳性。仅检测 MM 会漏诊 45%（192/427）的 MBT 反应，仅检测 MBT 会漏诊 29%（98/333）的 MM 反应。然而，这些“漏诊”反应中的大多数是可疑（+/-）或轻度（+）（MBT，65%；MM，78%），而对两者均呈阳性的患者中的大多数反应是中度（++）和/或强（+++）（52.3%）。手套是最常见的来源。

结论

由于以下原因，巯基苯并噻唑是巯基化合物的首选筛查变应原：（1）MM 漏诊反应的比例较高；（2）MM 漏诊组中可疑/轻度反应的比例较高；（3）对两者均呈阳性的患者中，对 MM 呈中度/强反应的比例较低（2%），对 MBT 呈可疑/轻度反应的比例较低，而相反的情况则较为常见（21%）。巯基混合物可能对辅助橡胶系列有用。