Angewandte Physikalische Chemie, Universität Heidelberg, Im Neuenheimer Feld 253, 69120 Heidelberg, Germany.
Phys Chem Chem Phys. 2013 Dec 28;15(48):20951-6. doi: 10.1039/c3cp52762j.
The effects of high hydrostatic pressure on the structure and dynamics of model membrane systems were investigated using neutron scattering. Diffraction experiments show shifts of the pre- and main-phase transitions of multilamellar vesicles of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) to higher temperatures with increased pressure which are close to results observed previously by other techniques, namely (10.4 ± 1.0) K kbar(-1) and (20.0 ± 0.5) K kbar(-1) for the two transitions. Backscattering spectroscopy reveals that the mean square displacements in the liquid phase are about 10% smaller at 300 bar and about 20% smaller at 600 bar compared to atmospheric pressure, whereas in the gel phase below the main phase transition the mean square displacements show a smaller difference in the dynamics of the three pressure values within the studied pressure range.
采用中子散射研究了高静水压力对模型膜系统结构和动力学的影响。衍射实验表明，1,2-二肉豆蔻酰-sn-甘油-3-磷酸胆碱（DMPC）的多层囊泡的预相和主相变向更高温度移动，随着压力的增加，这与先前用其他技术观察到的结果非常接近，即两个转变的压力系数分别为(10.4 ± 1.0) K kbar(-1)和(20.0 ± 0.5) K kbar(-1)。背散射光谱表明，与常压相比，在 300 巴时液相中的均方位移约小 10%，在 600 巴时约小 20%，而在主相变以下的凝胶相中，在所研究的压力范围内，三种压力值的动力学中均方位移的差异较小。
