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使用长效可逆避孕措施的头 6 个月内与停药相关的特征。

Characteristics associated with discontinuation of long-acting reversible contraception within the first 6 months of use.

机构信息

Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

出版信息

Obstet Gynecol. 2013 Dec;122(6):1214-21. doi: 10.1097/01.AOG.0000435452.86108.59.

Abstract

OBJECTIVE

To measure discontinuation within 6 months among users of the levonorgestrel intrauterine system, copper intrauterine device (IUD), and etonogestrel implant and identify baseline characteristics associated with early discontinuation.

METHODS

This was an analysis of the Contraceptive CHOICE Project, a cohort study of 9,256 participants provided with no-cost contraception and followed with telephone interviews at 3 and 6 months. We used logistic regression to investigate characteristics associated with early discontinuation of the two IUDs and implant and described reasons for discontinuation.

RESULTS

A total of 6,167 participants were eligible for this analysis. Follow-up data were available for 5,928 participants; 5,495 (93%) were using their method at 6 months and 433 (7%) had discontinued. Discontinuation rates were 7.3%, 8.0%, and 6.9% for the levonorgestrel intrauterine system, copper IUD, and implant, respectively. After adjusting for age, race, marital status, low socioeconomic status, and history of sexually transmitted infection, we found that unmarried women were slightly more likely to discontinue compared with married women (adjusted odds ratio [OR] 1.26, 95% confidence interval [CI] 1.01-1.59 and adjusted OR 1.62, 95% CI 1.11-2.37, respectively). No other baseline characteristics, including younger age (14-19 years), were associated with early discontinuation. The most common reason given for discontinuation was cramping among IUD users and irregular or frequent bleeding among implant users.

CONCLUSION

Rates of discontinuation of long-acting reversible contraception at 6 months is low and not increased in adolescents and young women. Intrauterine devices and the implant should be considered as first-line contraceptive options among all women to reduce unintended pregnancy.

LEVEL OF EVIDENCE

: II.

摘要

目的

测量左炔诺孕酮宫内节育系统、铜宫内节育器(IUD)和依托孕烯植入物使用者在 6 个月内的停药率,并确定与早期停药相关的基线特征。

方法

这是避孕选择项目的一项分析,该项目是一项队列研究,共纳入 9256 名参与者,提供免费避孕,并在 3 个月和 6 个月时进行电话访谈。我们使用逻辑回归分析了与两种 IUD 和植入物早期停药相关的特征,并描述了停药原因。

结果

共有 6167 名参与者符合本分析的条件。5928 名参与者有随访数据;5495 名(93%)在 6 个月时仍在使用他们的方法,433 名(7%)已停药。左炔诺孕酮宫内节育系统、铜 IUD 和植入物的停药率分别为 7.3%、8.0%和 6.9%。调整年龄、种族、婚姻状况、低社会经济地位和性传播感染史后,我们发现未婚女性与已婚女性相比,停药的可能性略高(调整后的优势比[OR]分别为 1.26,95%置信区间[CI]为 1.01-1.59 和 1.62,95%CI 为 1.11-2.37)。其他基线特征,包括年龄较小(14-19 岁),与早期停药无关。IUD 使用者停药的最常见原因是腹痛,而植入物使用者停药的最常见原因是不规则或频繁出血。

结论

在 6 个月时,长效可逆避孕方法的停药率较低,在青少年和年轻女性中并未增加。宫内节育器和植入物应被视为所有女性的首选避孕方法,以减少非意愿妊娠。

证据水平

II。

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