转移性或复发性胃肠癌患者循环肿瘤细胞 HER2 表达频率。
Frequency of HER2 expression of circulating tumour cells in patients with metastatic or recurrent gastrointestinal cancer.
机构信息
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
出版信息
Br J Cancer. 2013 Nov 26;109(11):2829-32. doi: 10.1038/bjc.2013.680. Epub 2013 Nov 7.
BACKGROUND
The clinical significance of circulating tumour cell (CTC) detection in gastrointestinal (GI) cancer remains controversial and the molecular biological characteristics of CTCs are poorly understood.
METHODS
A total of 87 patients with metastatic or recurrent GI cancer were prospectively enrolled. Circulating tumour cells and their HER2 status were assessed using the CellSearch System.
RESULTS
Among the 62 CTC-positive cases, we found 22 discordant cases (35.5%). Among the HER2-negative primary tumours, 17 of 54 developed HER2-positive CTCs. Five of eight had HER2-negative CTCs among the HER2-positive primary tumours.
CONCLUSION
The findings in the current study suggest that it is critical to evaluate the HER2 status of not only the primary tumour but also the CTCs because the metastasising tumour cells are the primary target of systemic therapy.
背景
循环肿瘤细胞（CTC）检测在胃肠道（GI）癌症中的临床意义仍存在争议，且 CTC 的分子生物学特征尚未被充分了解。
方法
共前瞻性纳入 87 例转移性或复发性胃肠道癌症患者。使用 CellSearch 系统评估循环肿瘤细胞及其 HER2 状态。
结果
在 62 例 CTC 阳性病例中，我们发现了 22 例不一致的病例（35.5%）。在 HER2 阴性的原发性肿瘤中，54 例中有 17 例出现了 HER2 阳性的 CTC。在 HER2 阳性的原发性肿瘤中，有 8 例中有 5 例出现了 HER2 阴性的 CTC。
结论
本研究的结果表明，评估不仅是原发性肿瘤，而且是 CTC 的 HER2 状态至关重要，因为转移的肿瘤细胞是系统治疗的主要目标。
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