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基于微流控芯片的癌症诊断及通过检测循环肿瘤细胞和循环癌干细胞预测复发

Microfluidic Chip-Based Cancer Diagnosis and Prediction of Relapse by Detecting Circulating Tumor Cells and Circulating Cancer Stem Cells.

作者信息

Cho Hyeon-Yeol, Choi Jin-Ha, Lim Joungpyo, Lee Sang-Nam, Choi Jeong-Woo

机构信息

Department of Bio & Fermentation Convergence Technology, Kookmin University, Seoul 02707, Korea.

Interdisciplinary Program for Bio-health Convergence, Kookmin University, Seoul 02707, Korea.

出版信息

Cancers (Basel). 2021 Mar 18;13(6):1385. doi: 10.3390/cancers13061385.

DOI:10.3390/cancers13061385
PMID:33803846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8003176/
Abstract

Detecting circulating tumor cells (CTCs) has been considered one of the best biomarkers in liquid biopsy for early diagnosis and prognosis monitoring in cancer. A major challenge of using CTCs is detecting extremely low-concentrated targets in the presence of high noise factors such as serum and hematopoietic cells. This review provides a selective overview of the recent progress in the design of microfluidic devices with optical sensing tools and their application in the detection and analysis of CTCs and their small malignant subset, circulating cancer stem cells (CCSCs). Moreover, discussion of novel strategies to analyze the differentiation of circulating cancer stem cells will contribute to an understanding of metastatic cancer, which can help clinicians to make a better assessment. We believe that the topic discussed in this review can provide brief guideline for the development of microfluidic-based optical biosensors in cancer prognosis monitoring and clinical applications.

摘要

检测循环肿瘤细胞（CTCs）被认为是液体活检中用于癌症早期诊断和预后监测的最佳生物标志物之一。使用CTCs的一个主要挑战是在存在血清和造血细胞等高噪声因素的情况下检测极低浓度的目标。本文综述了具有光学传感工具的微流控装置设计的最新进展及其在CTCs及其小恶性亚群——循环癌干细胞（CCSCs）检测和分析中的应用。此外，对分析循环癌干细胞分化的新策略的讨论将有助于理解转移性癌症，这可以帮助临床医生做出更好的评估。我们相信，本综述中讨论的主题可以为基于微流控的光学生物传感器在癌症预后监测和临床应用中的发展提供简要指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/15f727ac9357/cancers-13-01385-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/33f68e72ec3f/cancers-13-01385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/8b8106ef88e6/cancers-13-01385-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/d784567fa2b1/cancers-13-01385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/92f3e8815eb7/cancers-13-01385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/33dd42d998b8/cancers-13-01385-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/15f727ac9357/cancers-13-01385-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/33f68e72ec3f/cancers-13-01385-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/8b8106ef88e6/cancers-13-01385-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/d784567fa2b1/cancers-13-01385-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/92f3e8815eb7/cancers-13-01385-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/33dd42d998b8/cancers-13-01385-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2b6/8003176/15f727ac9357/cancers-13-01385-g005.jpg

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