Strasser H
Psychopharmacologia. 1975 Aug 21;43(2):145-56. doi: 10.1007/BF00421017.
The influence of Neoston--a relatively new analgesic, antipyretic, and anti-inflammatory agent--on performance in different tracking tests, on heart rate, on sinus arrhythmia and on subjective rating was objectivated. 15 healthy male and female subjects, aged from 19 to 27 years, took part in the sessions lasting about 2 1/2 hrs each. Two times two pills Neoston or a placebo were taken orally 2 and 5 hrs before the tests, making a total of 2 g. Performance in tracking was poorer on the whole with Neoston than with placebo, but only up to a maximum of 5%. Except one measurement point out of 10 all differences between the tests with the active drug and placebo were not statistically significant at the level of 5%. Yet a relatively uniform trend suggests a certain but only a small damping effect of Neoston. When relating the data of the second and third session on the data of the first session of each day, damping effects could be made more obvious. Hereby the influence of Neoston on tracking performance could be demonstrated to exist also statistically significant but to be practically almost irrelevant. In physiological variables as well as in subjective rating only small differences between the drug and placebo condition were measured. When relating the results to comparable research on the effects of alcohol, tranquilizers and stimulants, it is concluded that with Neoston in the relatively high dosage as used here, no real detrimental effects on traffic safety are to be expected.
对一种相对较新的镇痛、解热和抗炎药物Neoston在不同追踪测试中的表现、心率、窦性心律失常以及主观评分方面的影响进行了客观研究。15名年龄在19至27岁之间的健康男性和女性受试者参与了每次持续约2个半小时的测试环节。在测试前2小时和5小时，受试者口服两片两片装的Neoston或安慰剂，总量为2克。总体而言，服用Neoston时的追踪表现比服用安慰剂时差，但最多相差5%。在10个测量点中，除了一个点外，使用活性药物和安慰剂进行测试之间的所有差异在5%的水平上均无统计学意义。然而，一种相对一致的趋势表明Neoston有一定但只是很小的抑制作用。将每天第二次和第三次测试的数据与第一次测试的数据相关联时，抑制作用会更加明显。由此可以证明，Neoston对追踪表现的影响在统计学上也具有显著性，但实际上几乎无关紧要。在生理变量以及主观评分方面，药物和安慰剂状态之间仅测量到很小的差异。将结果与关于酒精、镇静剂和兴奋剂影响的可比研究相关联时，可以得出结论，使用此处所用的相对高剂量的Neoston，预计对交通安全不会有实际的有害影响。
