Yildiz Abdulkadir, Oylumlu Mustafa, Yuksel Murat, Aydin Mesut, Polat Nihat, Acet Halit, Akil Mehmet Ata, Bilik Mehmet Zihni, Kaya Hasan, Ertas Faruk
Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey
Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey.
Clin Appl Thromb Hemost. 2015 Jul;21(5):475-9. doi: 10.1177/1076029613509478. Epub 2013 Nov 6.
Inflammation has recently emerged in the pathogenesis of several cardiovascular disorders, including arrhythmias. The neutrophil-lymphocyte ratio (NLR) is a simple marker for the assessment of inflammatory status. Therefore, we aimed to investigate the relationship between the NLR and the ventricular premature contraction (VPC) existence. Patients aged between 18 and 40 years who were referred to the cardiology clinic were enrolled in the study. All patients' complete blood counts and 24-hour Holter recordings were analyzed. The NLR was higher within the VPC group compared to the control group (P < .001). According to the NLR tertiles, VPCs were more common in the higher NLR tertile (P < .001). A cutoff point of 1.80 for the NLR had 71% sensitivity and 60% specificity in predicting VPC in apparently healthy individuals. After multivariate analysis, only the NLR remained significant predictor of presence of VPC. In conclusion, the NLR is independently and significantly associated with VPC existence.
炎症最近在包括心律失常在内的几种心血管疾病的发病机制中显现出来。中性粒细胞与淋巴细胞比值（NLR）是评估炎症状态的一个简单指标。因此，我们旨在研究NLR与室性早搏（VPC）存在之间的关系。本研究纳入了转诊至心脏病诊所的18至40岁患者。分析了所有患者的全血细胞计数和24小时动态心电图记录。与对照组相比，VPC组的NLR更高（P <.001）。根据NLR三分位数，VPC在较高NLR三分位数中更常见（P <.001）。NLR的截断值为1.80时，在预测明显健康个体的VPC方面具有71%的敏感性和60%的特异性。多因素分析后，只有NLR仍然是VPC存在的显著预测因子。总之，NLR与VPC的存在独立且显著相关。
