Yilmaz Mustafa, Tenekecioglu Erhan, Arslan Burhan, Bekler Adem, Ozluk Ozlem Arican, Karaagac Kemal, Agca Fahriye Vatansever, Peker Tezcan, Akgumus Alkame
Department of Cardiology, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey.
Department of Cardiology, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey
Clin Appl Thromb Hemost. 2015 Jul;21(5):446-52. doi: 10.1177/1076029613507337. Epub 2013 Nov 6.
Leukocytes are reported as crucial not only for plaque activation but also in thrombus formation in acute coronary syndromes (ACSs). Among the markers of inflammation, in coronary artery disease neutrophil-lymphocyte ratio (NLR) has been reported to have the greatest predictive power of poor outcomes. Our aim was to evaluate the association of NLR with coronary thrombus in patients with non-ST-segment elevated ACSs (NST-ACSs). A total of 251 patients were hospitalized with a diagnosis of NST-ACS including non-ST-segment elevated myocardial infarction and unstable angina pectoris. Coronary angiographies were performed. In 167 patients, coronary thrombus was detected. Between the patient groups with and without coronary thrombus, neutrophil count, platelet count, and NLR are significantly increased, and lymphocyte count is significantly decreased in the group with coronary thrombus as compared to patient group without coronary thrombus. Leukocyte count and NLR may give an indication about the presence of coronary thrombus. In NST-ACS, blood parameters may give valuable information about the status of the coronary arteries.
白细胞不仅在斑块激活中起关键作用，在急性冠状动脉综合征（ACS）的血栓形成中也至关重要。在炎症标志物中，据报道在冠状动脉疾病中中性粒细胞与淋巴细胞比值（NLR）对不良预后具有最大的预测能力。我们的目的是评估非ST段抬高型ACS（NST-ACS）患者中NLR与冠状动脉血栓的关联。共有251例诊断为NST-ACS的患者住院，包括非ST段抬高型心肌梗死和不稳定型心绞痛。进行了冠状动脉造影。在167例患者中检测到冠状动脉血栓。与无冠状动脉血栓的患者组相比，有冠状动脉血栓的患者组中性粒细胞计数、血小板计数和NLR显著升高，淋巴细胞计数显著降低。白细胞计数和NLR可能提示冠状动脉血栓的存在。在NST-ACS中，血液参数可能提供有关冠状动脉状况的有价值信息。
