Kaboev O K, Luchkina L A, Bekker M L
Biokhimiia. 1986 Jan;51(1):146-9.
Cationic proteins--cytochrome c and pancreatic RNAase--possess the apurinic-apyrimidinic DNA-endonuclease activity. The affinity of these proteins for DNA-apurinic sites does not differ from that of specific apurinic DNA-endonucleases described in literature. The main features of the apurinic activity of cationic proteins are as follows: low specific activity, high temperature optimum of the reaction, absence of primer-stimulated activity. The feasibility of participation of cationic proteins and some other nucleophilic compounds in single-stranded breaks production in apurinic DNA is discussed.
阳离子蛋白——细胞色素c和胰腺核糖核酸酶——具有脱嘌呤-脱嘧啶DNA内切酶活性。这些蛋白对DNA脱嘌呤位点的亲和力与文献中描述的特异性脱嘌呤DNA内切酶的亲和力并无差异。阳离子蛋白脱嘌呤活性的主要特点如下：比活性低、反应的最适温度高、不存在引物刺激活性。本文讨论了阳离子蛋白和其他一些亲核化合物参与脱嘌呤DNA中单链断裂产生的可能性。
